Gammaherpesvirus persistence alters key CD8 T-cell memory characteristics and enhances antiviral protection
| Autor: | Edward J. Usherwood, Joshua J. Obar, Erica K. Leung, Sarah C. Bellfy, Shinichiro Fuse |
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| Rok vydání: | 2006 |
| Předmět: |
viruses
Immunology Immunodominance CD8-Positive T-Lymphocytes Lymphocyte Activation Microbiology Virus Mice Immune system Gammaherpesvirinae Virology Virus latency medicine Cytotoxic T cell Animals Mice Inbred BALB C biology Herpesviridae Infections medicine.disease Virus Latency Mice Inbred C57BL Chronic infection Granzyme Insect Science biology.protein Pathogenesis and Immunity Immunologic Memory CD8 |
| Zdroj: | Journal of virology. 80(17) |
| ISSN: | 0022-538X |
| Popis: | In herpesvirus infections, the virus persists for life but is contained through T-cell-mediated immune surveillance. How this immune surveillance operates is poorly understood. Recent studies of other persistent infections have indicated that virus persistence is associated with functional deficits in the CD8+T-cell response. To test whether this is the case in a herpesvirus infection, we used a mutant murine gammaherpesvirus that is defective in its ability to persist in the host. By comparing the immune response to this virus with a revertant virus that can persist, we were able to dissect the changes in the antiviral CD8+T-cell response that are induced by virus persistence. Surprisingly, persistently infected mice controlled a secondary challenge infection more rapidly than nonpersistently infected mice, indicating enhanced rather than diminished effector functions. Consistent with this, virus-specific CD8 T cells from these mice exhibited faster upregulation of the cytotoxic mediator granzyme B. Another unexpected finding was that CD8+T cells from neither infection responded efficiently to homeostatic cytokines. The unresponsiveness of the memory cells from the nonpersistently infected mice appears to be linked to the prolonged replication of virus within the lungs. Other changes seen in different chronic infection models were also observed, such as changes in Bcl-2 levels, interleukin-2 production, and the immunodominance hierarchy. These data show persistence of gammaherpesvirus type 68 alters the properties of CD8+T cells and illustrates that immune surveillance does not require CD8 T cells with the same attributes as “classical” memory CD8+T cells. |
| Databáze: | OpenAIRE |
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