Neuropharmacology of brain-stimulation-evoked aggression
| Autor: | Thomas A.P. Roeling, Menno R. Kruk, Thomas R Gregg, Allan Siegel |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Cognitive Neuroscience Poison control Behavioral Neuroscience chemistry.chemical_compound Neuropharmacology Internal medicine Neuromodulation medicine Animals Neurotransmitter Brain Mapping Behavior Animal Aggression Glutamate receptor Evoked Potentials Motor Stimulation Chemical Serenic Neuropsychology and Physiological Psychology Endocrinology medicine.anatomical_structure chemistry Brain stimulation medicine.symptom Psychology Neuroscience |
| Zdroj: | Neuroscience & Biobehavioral Reviews. 23:359-389 |
| ISSN: | 0149-7634 |
| DOI: | 10.1016/s0149-7634(98)00040-2 |
| Popis: | Evidence is reviewed concerning the brain areas and neurotransmitters involved in aggressive behavior in the cat and rodent. In the cat, two distinct neural circuits involving the hypothalamus and PAG subserve two different kinds of aggression: defensive rage and predatory (quiet-biting) attack. The roles played by the neurotransmitters serotonin, GABA, glutamate, opioids, cholecystokinin, substance P, norepinephrine, dopamine, and acetylcholine in the modulation and expression of aggression are discussed. For the rat, a single area, largely coincident with the intermediate hypothalamic area, is crucial for the expression of attack; variations in the rat attack response in natural settings are due largely to environmental variables. Experimental evidence emphasizing the roles of serotonin and GABA in modulating hypothalamically evoked attack in the rat is discussed. It is concluded that significant progress has been made concerning our knowledge of the circuitry underlying the neural basis of aggression. Although new and important insights have been made concerning neurotransmitter regulation of aggressive behavior, wide gaps in our knowledge remain. |
| Databáze: | OpenAIRE |
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