Involvement of transforming growth factor beta-1 (TGFβ1) cytokine and FOXP3 transcription factor genetic polymorphisms in hematological malignancies
| Autor: | Roberta Losi Guembarovski, Glauco Akelinghton Freire Vitiello, Marla Karine Amarante, Carlos Eduardo Coral de Oliveira, Aparecida de Lourdes Perim, Maria Angelica Ehara Watanabe |
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| Rok vydání: | 2015 |
| Předmět: |
biology
FOXP3 lcsh:Biotechnology medicine.medical_treatment T cell Transforming growth factor beta Odds ratio susceptibility Hematological malignancies Cytokine medicine.anatomical_structure lcsh:TP248.13-248.65 TGFB1 Genotype Immunology biology.protein medicine Cancer research genetic polymorphism Transcription factor Genetic association |
| Zdroj: | Brazilian Archives of Biology and Technology v.58 n.4 2015 Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR Brazilian Archives of Biology and Technology, Vol 58, Iss 4, Pp 553-561 (2015) Brazilian Archives of Biology and Technology, Volume: 58, Issue: 4, Pages: 553-561, Published: 01 MAY 2015 |
| ISSN: | 1678-4324 |
| DOI: | 10.1590/s1516-8913201500287 |
| Popis: | Hematological malignancies (HM) are a group of neoplastic diseases that arise from hematologic cell lineages. Transforming growth factor beta 1 (TGFβ1) is shown to negatively regulate normal and malignant hematopoiesis and, in immunological context, to promote T cell exhaustion and generation of regulatory T cells, which are shown to be deleterious in cancer, by the induction of transcription factor FOXP3 expression. The present study aimed to evaluate TGFB1 exon-1 rs1800470 and FOXP3 intron-1 rs2232365 polymorphisms in relation to HM susceptibility. DNA was extracted from blood samples of 43 HM patients and 142 neoplasia-free individuals and polymorphisms were analyzed by allelic-specific PCR. Association analysis was assessed by the Odds Ratio (OR) with significance level of 5%. Regarding FOXP3 polymorphism, no significant differences were observed in genotype or allele distribution among the patients and controls. However, there was a positive association between TGFB1 TT genotype and HM susceptibility (OR = 4.07; CI95% = 1.94 - 8.52). In the combined analysis, a positive association was also observed for TGFB1 TT and FOXP3 GG genotypes (OR = 4.00; CI95% = 1.54 - 10.41) in relation to HM susceptibility. Our results indicated promising new markers to be further investigated in hematological malignancies. |
| Databáze: | OpenAIRE |
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