Simultaneous determination of (R)- and (S)-naproxen and (R)- and (S)-6-O-desmethylnaproxen by high-performance liquid chromatography on a Chiral-AGP column
| Autor: | Steen Honoré Hansen, Jan Vanggaard Andersen |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Naproxen
Chromatography Chemistry Metabolite Stereoisomerism General Chemistry High-performance liquid chromatography Biological fluid Rats Rats Sprague-Dawley chemistry.chemical_compound Spectrometry Fluorescence Desmethylnaproxen Biological fluids medicine Animals Separation method Female Enantiomer Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | Journal of Chromatography B: Biomedical Sciences and Applications. 577:362-365 |
| ISSN: | 0378-4347 |
| DOI: | 10.1016/0378-4347(92)80260-w |
| Popis: | A high-performance liquid chromatographic method for the simultaneous determination of both enantiomers of naproxen and its metabolite 6-O-desmethylnaproxen has been developed. The separation is performed on a column containing α1-acid glycoprotein as the chiral selector. The method has been used for the determination of the enantiomeric purity of the drug substance and the metabolite, and for the simultaneous determination of all four compounds in biological fluids. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|