Investigating binding mechanism of thymoquinone to human transferrin, targeting Alzheimer's disease therapy

Autor:	Bin Xue, Debarati DasGupta, Manzar Alam, Mohd Shahnawaz Khan, Shuo Wang, Anas Shamsi, Asimul Islam, Md. Imtaiyaz Hassan
Rok vydání:	2022
Předmět:	Molecular Docking Simulation Alzheimer Disease Iron Benzoquinones Transferrin Humans Cell Biology Molecular Biology Biochemistry
Zdroj:	Journal of Cellular Biochemistry. 123:1381-1393
ISSN:	1097-4644 0730-2312
DOI:	10.1002/jcb.30299
Popis:	Iron deposition in the central nervous system (CNS) is one of the causes of neurodegenerative diseases. Human transferrin (hTf) acts as an iron carrier present in the blood plasma, preventing it from contributing to redox reactions. Plant compounds and their derivatives are frequently being used in preventing or delaying Alzheimer's disease (AD). Thymoquinone (TQ), a natural product has gained popularity because of its broad therapeutic applications. TQ is one of the significant phytoconstituent of Nigella sativa. The binding of TQ to hTf was determined by spectroscopic methods and isothermal titration calorimetry. We have observed that TQ strongly binds to hTf with a binding constant (K) of 0.22 × 10
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ddcd87629efa534c6655a5fa6c87bf https://doi.org/10.1002/jcb.30299 Zobrazit plný text záznamu Plný text