Can the epoxides of cinnamyl alcohol and cinnamal show new cases of contact allergy?

Autor:	Ann-Therese Karlberg, Kristina Luthman, Lina Hagvall, Ida B. Niklasson
Rok vydání:	2018
Předmět:	Adult Male 0301 basic medicine medicine.medical_specialty Propanols Metabolite Alcohol Dermatology Patch testing Dermatitis Atopic 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Humans Immunology and Allergy Medicine Fragrance mix Cinnamyl alcohol business.industry Patch test Allergens Patch Tests Perfume 030104 developmental biology Fragrance allergy chemistry Contact allergy Dermatitis Allergic Contact Female business
Zdroj:	Contact Dermatitis. 78:399-405
ISSN:	1600-0536 0105-1873
Popis:	Background Cinnamyl alcohol is considered to be a prohapten and prehapten with cinnamal as the main metabolite. However, many individuals who are allergic to cinnamyl alcohol do not react to cinnamal. Sensitizing epoxides of cinnamyl alcohol and cinnamal have been identified as metabolites and autoxidation products of cinnamyl alcohol. Objective To investigate the clinical relevance of contact allergy to epoxycinnamyl alcohol and epoxycinnamal. Methods Irritative effects of the epoxides were investigated in 12 dermatitis patients. Epoxycinnamyl alcohol and epoxycinnamal were patch tested in 393 and 390 consecutive patients, respectively. In parallel, cinnamyl alcohol and cinnamal were patch tested in 607 and 616 patients, respectively. Results Both epoxides were irritants, but no more positive reactions were detected than when testing was performed with cinnamyl alcohol and cinnamal. Late allergic reactions to epoxycinnamyl alcohol were observed. In general, patients with late reactions showed doubtful or positive reactions to cinnamal and fragrance mix I at regular patch testing. Conclusion The investigated epoxides are not important haptens in contact allergy to cinnamon fragrance. The high frequency of fragrance allergy among patients included in the irritancy study showed the difficulty of suspecting fragrance allergy on the basis of history; patch testing broadly with fragrance compounds is therefore important.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3dd627e71dbda38522471a7f07188e9 https://doi.org/10.1111/cod.12992 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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