Development of pressure-sensitive dosage forms with a core liquefying at body temperature
| Autor: | Grzegorz Garbacz, Mona Bock, Werner Weitschies, Lisa Wilde, Marieke Wolf, Gunnar Glöckl |
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| Rok vydání: | 2013 |
| Předmět: |
Absorption (pharmacology)
medicine.medical_specialty Chemistry Pharmaceutical Pharmaceutical Science Polyethylene glycol engineering.material Cellulose acetate film Dosage form Body Temperature chemistry.chemical_compound Coating medicine Pressure Dissolution testing Composite material Triglycerides Active ingredient Dosage Forms Gastric emptying General Medicine Microspheres Surgery chemistry Solubility engineering Stress Mechanical Pharmaceutical Vehicles Biotechnology |
| Zdroj: | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 86(3) |
| ISSN: | 1873-3441 |
| Popis: | Pressure-sensitive dosage forms have been developed that are intended for pulsatile delivery of drugs to the proximal small intestine. The novel dosage forms are composed of insoluble shell and either a hard fat W32 or polyethylene glycol (PEG) 1000 core that are both liquidizing at body temperature. The release is triggered by predominant pressure waves such as contractions of the pylorus causing rupture of the shell and an immediate emptying of the liquefied filling containing the active ingredient. In consequence immediately after the trigger has been effective the total amount of the drug is intended to be available for absorption in the upper small intestine. Both core types were coated with a cellulose acetate film that creates a pressure-sensitive shell in which mechanical resistance is depending on the coating thickness. Results of the texture analysis confirmed a correlation between the polymer load of the coating and the mechanical resistance. The dissolution test performed under conditions of physiological meaningful mechanical stress showed that the drug release is triggered by pressure waves of ⩾300 mbar which are representing the maximal pressure occurring during the gastric emptying. |
| Databáze: | OpenAIRE |
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