Transmural gradients of cardiac myofiber shortening in aortic valve stenosis patients using MRI tagging
| Autor: | Theo Arts, Jos G. Maessen, A. van der Toorn, Gabriel Snoep, F. H. Van der Veen, Frits W. Prinzen, Tammo Delhaas, Paul Barenbrug |
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| Rok vydání: | 2002 |
| Předmět: |
Aortic valve disease
Male medicine.medical_specialty Torsion Abnormality Physiology Muscle Fibers Skeletal Ventricular Function Left Aortic valve replacement Physiology (medical) Internal medicine Tissue damage medicine Humans Aged business.industry Myocardium Models Cardiovascular Aortic Valve Stenosis Middle Aged medicine.disease Cardiac myofiber Magnetic Resonance Imaging Stenosis Aortic valve stenosis Heart Valve Prosthesis Circulatory system Cardiology Female Cardiology and Cardiovascular Medicine business Perfusion |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0363-6135 |
| Popis: | Aortic valve stenosis impairs subendocardial perfusion with a risk of irreversible subendocardial tissue damage. A likely precursor of damage is subendocardial contractile dysfunction, expressed by the parameter TransDif, which is defined as epicardial minus endocardial myofiber shortening, normalized to the mean value. With the use of magnetic resonance tagging in two short-axis slices of the left ventricle (LV), TransDif was derived from LV torsion and contraction during ejection. TransDif was determined in healthy volunteers (control, n = 9) and in patients with aortic valve stenosis before (AVSten, n = 9) and 3 mo after valve replacement (AVRepl, n = 7). In the control group, TransDif was 0.00 ± 0.14 (mean ± SD). In the AVSten group, TransDif increased to 0.96 ± 0.62, suggesting impairment of subendocardial myofiber shortening. In the AVRepl group, TransDif decreased to 0.37 ± 0.20 but was still elevated. In eight of nine AVSten patients, the TransDif value was elevated individually ( P < 0.001), suggesting that the noninvasively determined parameter TransDif may provide important information in planning of treatment of aortic valve stenosis. |
| Databáze: | OpenAIRE |
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