Early cognitive impairment along with decreased stress-induced BDNF in male and female patients with newly diagnosed multiple sclerosis
| Autor: | Miroslav Vlcek, Barbora Prokopova, Natasa Hlavacova, Alexandra Garafova, Lucia Grunnerova, Adela Penesova, Branislav Kollár, Peter Turcani, Daniela Jezova |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Multiple Sclerosis Immunology 03 medical and health sciences 0302 clinical medicine Copeptin Surveys and Questionnaires Internal medicine medicine Humans Immunology and Allergy Cognitive Dysfunction Effects of sleep deprivation on cognitive performance Psychiatry Cognitive deficit Depression (differential diagnoses) Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor Multiple sclerosis medicine.disease 030104 developmental biology Neurology Anxiety Female Neurology (clinical) medicine.symptom Psychology Biomarkers Stress Psychological 030217 neurology & neurosurgery Stroop effect |
| Zdroj: | Journal of Neuroimmunology. 302:34-40 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2016.11.007 |
| Popis: | The aim of this study was to evaluate neuroendocrine activation during stress in patients with recently diagnosed multiple sclerosis before starting the immunomodulatory therapy (EDSS score≤2.0). We verified the hypothesis that certain cognitive and affective dysfunction is present already at this early stage of the disease. The sample consisted of 38 subjects, which involved patients who were recently diagnosed multiple sclerosis and age- and sex-matched healthy volunteers. Stroop test served as mental stress model enabling measurement of cognitive performance. Present results showed increased state anxiety, depression scores and poorer performance in the Stroop test in the group of patients compared to healthy subjects. The cognitive dysfunction was particularly evident in male patients with simultaneously decreased concentrations of the brain-derived neurotrophic factor (BDNF) in plasma. The patients at this stage of the disease have not yet developed the hyperactivity of the hypothalamic-pituitary-adrenocortical axis. They showed normal levels of plasma copeptin and reduced aldosterone response to mental stress test in women only. Concentrations of plasma copeptin were higher in men compared to women. Very early stages of multiple sclerosis are accompanied by disturbances in psychological well-being, mild cognitive dysfunction and decreased plasma concentrations of BDNF, particularly in male patients. |
| Databáze: | OpenAIRE |
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