In vitro characterization of response to stimulus (wounding) with regard to ageing in human skin fibroblasts

Autor:	A.L. Muggleton-Harris, R.L. Burghoff, Patricia S. Reisert
Rok vydání:	1982
Předmět:	Wound Healing Aging Pathology medicine.medical_specialty Chemistry Human skin Fibroblasts Stimulus (physiology) Donor age In vitro Cell biology In vivo Ageing medicine Humans Cells Cultured Population doubling Confluent monolayer Skin Developmental Biology
Zdroj:	Mechanisms of Ageing and Development. 19:37-43
ISSN:	0047-6374
DOI:	10.1016/0047-6374(82)90048-3
Popis:	Confluent cultured normal human skin fibroblasts from neonatal, adult and aged donors have been stimulated to respond to wounding of the cell sheet. The latent period prior to initial migration of cells from the leading edge of the monolayer is correlated with in vitro population doubling level and in vivo donor age. Time-lapse photography of areas along the edge of the cell sheet reveals a specific pattern of migration by which the cells reestablish a confluent monolayer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3dafd997ecac4015fcb73eebea28dc4 https://doi.org/10.1016/0047-6374(82)90048-3 Zobrazit plný text záznamu