A Modified Formulation of Sutaehwan Ameliorates Menopausal Anxiety, Depression and Heart Hypertrophy in the VCD-Induced Menopausal Mouse Model
Autor: | Seung Hee Han, Songhee Jeon, Ha Jin Jeong, Quan Feng Liu, Deok-Ho Kim, Dong-Il Kim |
---|---|
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Vinyl Compounds Uterus Pharmaceutical Science Estrogen receptor Ovary Cardiomegaly Anxiety 03 medical and health sciences 0302 clinical medicine Neurotrophic factors Internal medicine Cyclohexenes Medicine Animals Humans Protein kinase A Protein kinase B Pharmacology business.industry Depression Plant Extracts General Medicine medicine.disease Medicine Korean Traditional Menopause Mice Inbred C57BL Disease Models Animal 030104 developmental biology Endocrinology medicine.anatomical_structure 030220 oncology & carcinogenesis Ovariectomized rat MCF-7 Cells Female business |
Zdroj: | Biologicalpharmaceutical bulletin. 42(9) |
ISSN: | 1347-5215 |
Popis: | Sutaehwan (STH) has been used in Korean medicine for the treatment of abortus habitualis such as fetal restlessness in the uterus. Previously, we reported that a modified formulation of STH, Sutaehwan-Gami, has phytoestrogen-like properties in an ovariectomized menopausal rat model. However, the therapeutic effects of STH and the precise mechanisms by which STH affects various menopausal symptoms remain poorly understood. The current study was designed to explore the effects of a modified form of STH on menopausal anxiety, depression and heart hypertrophy and its mechanisms in 4-vinylcyclohexene diepoxide (VCD)-induced menopausal mouse models. VCD-induced menopausal model mice were fed a modified form of STH, which contained water extract of 3 herbs (called STH_KP17001) at a dose of 100 or 300 mg/kg/d or as a positive control, estradiol at a dose of 0.2 mg/kg/d with standard mouse pellets for 13 weeks. The results show that STH_KP17001 significantly restored the VCD-induced weight reduction of uterine and ovary through the phosphorylation of extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) in the uterus and ovary. Moreover, STH_KP17001 showed slight proliferative effects and estrogen receptor α phosphorylation in MCF-7 cells. Treatment with STH_KP17001 reversed VCD-induced anxiety and depression through AMP-activated protein kinase (AMPK) activation and brain-derived neurotrophic factor (BDNF) expression in the cerebral cortex, while improving heart hypertrophy through inactivation of inhibitor of kappaB α (IκBα) in the heart. The results indicate that STH_KP17001 improves menopause-induced anxiety, depression and heart hypertrophy, implying its protective role for the management of menopausal symptoms. |
Databáze: | OpenAIRE |
Externí odkaz: |