Assessment of tubule occlusion properties of an experimental stannous fluoride toothpaste: A randomised clinical in situ study
| Autor: | Nicola Hellin, Emma L Macdonald, SB Jones, Joon Seong, Jonathan E. Creeth, Nicola X West |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male business.product_category Dentin Desensitizing Agents Dentine hypersensitivity Dentistry 02 engineering and technology Sodium monofluorophosphate 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine in situ model Occlusion Medicine Dentine Hypersensitivity Humans Single-Blind Method General Dentistry Orange juice toothpaste crossover Toothpaste Stannous fluoride business.industry Tubule occlusion 030206 dentistry Dentin Sensitivity Middle Aged 021001 nanoscience & nanotechnology Dentineal tubule occlusion Dentinal Tubule Treatment Outcome chemistry Dentin Microscopy Electron Scanning Tin Fluorides Female 0210 nano-technology business Fluoride Toothpastes |
| Zdroj: | West, N, Seong, J, Hellin, N, Macdonald, E, Jones, S & Creeth, J 2018, ' Assessment of tubule occlusion properties of an experimental stannous fluoride toothpaste : a randomised clinical in situ study ', Journal of Dentistry, vol. 76, pp. 125-131 . https://doi.org/10.1016/j.jdent.2018.07.001 |
| ISSN: | 1879-176X 0276-8194 |
| DOI: | 10.1016/j.jdent.2018.07.001 |
| Popis: | fluoride toothpaste: a randomised clinical in situ study Objectives: To evaluate the ability of a modified in situ model to differentiate dentinal tubule occlusion properties of toothpaste formulations over 10 days of treatment. Methods: This was a single-centre, three-treatment period, crossover, randomised, single-blind study with healthy participants wearing two lower oral appliances, each retaining four dentine samples, for 10 treatment days during each period of the study. Samples were power-brushed ex vivo twice on each treatment day with a Test toothpaste containing 0.454% stannous fluoride, a Control fluoride toothpaste containing 0.76% sodium monofluorophosphate, or mineral water. Dentine samples were subjected to in situ acid challenge (orange juice) on Days 9 and 10. Scanning electron microscopy images obtained at baseline and after 1, 4, 8 and 10 days of treatment were graded for degree of surface coverage by four calibrated examiners; the primary study endpoint was Day 8. Results: After 4, but not 8, days’ treatment, the degree of tubule occlusion increased in the dentine samples treated with the Test or Control toothpastes compared with the water-treated samples (p |
| Databáze: | OpenAIRE |
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