Multi-centre clinical study evaluating the efficacy of SonoVue™ (BR1), a new ultrasound contrast agent in Doppler investigation of focal hepatic lesions
| Autor: | Wilson J. Angerson, S Yarmenitis, C Pezzoli, G Maresca, G Bongartz, Martin J. K. Blomley, A. Del Maschio, J.B Llull, Edward Leen, Vincenzo Summaria |
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| Rok vydání: | 2002 |
| Předmět: |
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medicine.medical_specialty Time Factors media_common.quotation_subject Sulfur Hexafluoride Contrast Media symbols.namesake Vascularity Text mining Predictive Value of Tests Positive predicative value medicine Humans Contrast (vision) Radiology Nuclear Medicine and imaging Phospholipids media_common business.industry Liver Neoplasms Ultrasound Videotape Recording Ultrasonography Doppler General Medicine Middle Aged symbols Microbubbles Female Histopathology Radiology medicine.symptom business Doppler effect |
| Zdroj: | European Journal of Radiology. 41:200-206 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/s0720-048x(01)00457-0 |
| Popis: | Objectives: SonoVue™ is a new ultrasound contrast agent, which consists of stabilised microbubbles of a sulphur hexafluoride gas. The aim of the study was to assess its efficacy in the Doppler investigation of focal hepatic lesions. Materials and methods: Seventy patients with focal liver tumours were studied. Four doses (0.3, 0.6, 1.2 and 2.4 ml) of SonoVue™ were administered intravenously with at least 10 min delay between each injection. A complete colour/power and spectral Doppler imaging investigation of the lesions was performed at baseline pre-dosing and after each SonoVue injection. All examinations were recorded on SVHS videotapes. Baseline and post contrast videotapes were reviewed by the on-site (un-blinded) investigators and by two off-site blinded readers (a) to grade the global quality of the Doppler scans of the focal lesions vascularity and the normal parenchymal vessels (b) to measure the duration of clinically useful Doppler signal enhancement and (c) to determine the diagnostic accuracy and performance of the enhanced versus unenhanced scans using histopathology, tumour markers, CT and/or MR as the reference standard. Results: A statistically significant improvement was observed at all four SonoVue doses in the off site assessment of global quality of the Doppler examination of tumoral and normal parenchymal vessels in comparison with the baseline (P |
| Databáze: | OpenAIRE |
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