Association of air pollution with cognitive functions and its modification by APOE gene variants in elderly women
| Autor: | Tamara Schikowski, Dorothee Sugiri, Il-seok Bae, Nicole Probst-Hensch, Lilian Tzivian, Andrea Vierkötter, Tom Teichert, Ursula Krämer, Ulrich Ranft, Christian Luckhaus, Thomas Schulte, Mohammad Vossoughi, Karin Fehsel, Barbara Hoffmann, Christian Herder |
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| Rok vydání: | 2015 |
| Předmět: |
Gerontology
Apolipoprotein E Rural Population medicine.medical_specialty Urban Population Apolipoprotein E4 Neuropsychological Tests Biochemistry Cohort Studies Cognition Interquartile range Environmental health Air Pollution Germany Epidemiology Medicine Humans Cognitive skill Effects of sleep deprivation on cognitive performance Particle Size General Environmental Science Aged Polymorphism Genetic business.industry Environmental Exposure Data Interpretation Statistical Cohort Female Particulate Matter business Neurocognitive |
| Zdroj: | Environmental research. 142 |
| ISSN: | 1096-0953 |
| Popis: | Background Epidemiological studies have shown effects of long-term exposure to air pollution on cardiovascular and respiratory health. However, studies investigating the effects of air pollution on cognition and brain function are limited. We investigated if neurocognitive functions are associated with air pollution exposure and whether apolipoprotein E (ApoE) alleles modify the association of air pollution exposure with cognition. Methods We investigated 789 women from the SALIA cohort during the 22-year follow-up examination (2008–2009). Exposure to particulate matter (PM) size fractions and nitrogen oxides (NOx) were assigned to home addresses. Traffic indicators were used to assess residential proximity to high traffic load. Level of cognitive performance was assessed using the CERAD-Plus test. Air pollution effects on cognitive functioning were estimated cross-sectionally using adjusted linear regression models. Results Air pollution was negatively associated with cognitive function and cognitive performance in the subtests for semantic memory and visuo-construction. Significant associations could be observed for figure copying with an interquartile range increase of NO2 (β=–0.28 (95%CI:–0.44;–0.12)), NOx (β=–0.25 (95%CI:–0.40;–0.09)), PM10 (β=–0.14 (95%CI:–0.26;–0.02)) and PM2.5 (β=–0.19 (95%CI:–0.36;–0.02)). The association with traffic load was significant in carriers of one or two ApoE ɛ4 risk alleles. Conclusion In this study of elderly women, markers of air pollution were associated with cognitive impairment in the visuospatial domain. The association of traffic exposure is significant in participants carrying the ApoE e4 risk allele. |
| Databáze: | OpenAIRE |
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