Pharmaceutical biotechnological potential of filamentous fungi isolated from textile industry
| Autor: | Viviane Piccin dos Santos, Valéria Maia de Oliveira, María Elisa Peichoto, Micaela Andrea Gritti, Júlia Ronzella Ottoni, Suzan Prado Fernandes Bernal, Michel Rodrigo Zambrano Passarini |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Microorganism Microbial Sensitivity Tests Wastewater Secondary metabolite medicine.disease_cause Biochemistry Microbiology 03 medical and health sciences Microbial ecology Genetics medicine Extracellular Molecular Biology 030304 developmental biology 0303 health sciences Protease Bacteria biology 030306 microbiology Fungi Pathogenic bacteria General Medicine Antimicrobial biology.organism_classification Textile Industry Penicillium Biotechnology medicine.drug |
| Zdroj: | Archives of Microbiology. 203:3933-3944 |
| ISSN: | 1432-072X 0302-8933 |
| Popis: | The need for more effective drugs for the treatment of infectious diseases as well as for general applications including wound healing and burn surgery, has guided efforts for the discovery of new compounds of medical interest. Microorganisms found in textile industrial waste have the ability to produce a variety of enzymes and/or secondary metabolites including molecules of pharmaceutical interest. The present work investigated the biotechnological potential of filamentous fungi isolated from textile industry wastewater for the production of collagenase and antimicrobial metabolites. From 28 isolates assayed, Sarocladium sp. ITF33 showed specific collagenolytic activity with values of 7.62 and 9.04 U mg−1 for the intracellular and extracellular fractions, respectively. The isolate Penicillium sp. ITF28 showed the best antimicrobial activity, reaching MIC ranging from 1.0 to 0.0625 mg mL−1 against five pathogenic bacteria. Molecular analyzes suggest that the isolate Sarocladium sp. ITF 33 can be considered a species not yet described. The results of the present work encourage studies of characterization and purification of the enzymes and secondary metabolites produced by the isolates found aiming future applications in the medical and pharmaceutical fields. |
| Databáze: | OpenAIRE |
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