Extensive Endoscopic Image-Guided Sinus Surgery Decreases BPI-ANCA in Patients with Cystic Fibrosis
| Autor: | Kasper Aanaes, Helle Krogh Johansen, Tanja Pressler, Niels Rasmussen, Niels Høiby, Malin Carlsson, Christian von Buchwald, Ulrika Lindberg, Jörgen Wieslander, Mårten Segelmark |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Medicin och hälsovetenskap Adolescent Cystic Fibrosis Immunology urologic and male genital diseases Cystic fibrosis Medical and Health Sciences Antibodies Antineutrophil Cytoplasmic Immunomodulation Young Adult immune system diseases Paranasal Sinuses medicine Humans Pseudomonas Infections In patient cardiovascular diseases Child skin and connective tissue diseases business.industry Autoantibody Endoscopy Blood Proteins General Medicine Middle Aged Sinus surgery medicine.disease Antibodies Bacterial humanities respiratory tract diseases Treatment Outcome Surgery Computer-Assisted Pseudomonas aeruginosa Female business Biomarkers Antimicrobial Cationic Peptides Endoscopic image |
| Popis: | Antineutrophil cytoplasm autoantibodies (ANCA) directed against bactericidal/permeability-increasing protein (BPI) are common in patients with cystic fibrosis (CF), and serum levels are correlated with lung colonization by Pseudomonas aeruginosa and the severity of lung damage. The production of BPI-ANCA may be due to the costimulation of BPI when mounting an immune response against P. aeruginosa. The effect of surgery aiming to eradicate bacteria and infected tissue on BPI-ANCA levels is sparsely described. A cohort of patients with CF were included: 53 patients having extensive image-guided sinus surgery (EIGSS) with topical postoperative antibiotic treatment, 131 non-operated controls and 36 who had double lung transplantation (LTX). In all 219 patients, serum samples before and after surgery or at similar intervals were analysed for IgG and IgA BPI-ANCA. The EIGSS group showed a highly significant decrease in both IgA and IgG BPI-ANCA levels compared with their own preoperative values and control group values (P andlt; 0.0010.02). The LTX patients also showed a highly significant decrease in both IgA and IgG BPI-ANCA levels (P andlt; 0.001). EIGSS and LTX decrease IgA and IgG BPI-ANCA levels in patients with CF, indicating that extensive removal of infected tissue influences the pathogenic process of autoantibody production. The results shown herein are in favour of applying EIGSS in selected patients with CF and for using BPI-ANCA as a surrogate marker for guiding further therapeutic interventions. Funding Agencies|Statens Serum Institut||Candys Foundation |
| Databáze: | OpenAIRE |
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