Therapeutic Approaches to Chronic Intestinal Inflammation by Specific Targeting of Mucosal IL-7 / IL-7R Signal Pathway
| Autor: | Akihiro Araki, Tetsuya Nakamura, Motomi Yamazaki, Shinya Ohoka, Ryuichi Okamoto, Mamoru Watanabe, Takanori Kanai |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
Receptors Interleukin-7 Mucosal Immune Responses Lymphoid Tissue business.industry Interleukin-7 Immunology Interleukin medicine.disease Inflammatory bowel disease Signal pathway Intestinal Diseases Drug Delivery Systems Chronic disease Intestinal inflammation Chronic Disease Animals Humans Immunology and Allergy Medicine Intestinal Mucosa business Receptor Signal Transduction |
| Zdroj: | Current Drug Target -Inflammation & Allergy. 2:119-123 |
| ISSN: | 1568-010X |
| DOI: | 10.2174/1568010033484269 |
| Popis: | Inflammatory bowel disease is thought to result from inappropriate activation of mucosal immune responses. Intestinal epithelial cells produce interleukin (IL)-7 that serves as a regulatory factor for IL-7 receptor (IL-7R)(+) mucosal lymphocytes. The pivotal role of mucosal IL-7/IL-7R dependent signals in the activation of mucosal immune responses that lead to the development of chronic intestinal inflammation are demonstrated. Therapeutic approaches targeting IL-7/IL-7R signal pathway may be feasible in the treatment of inflammatory bowel disease. |
| Databáze: | OpenAIRE |
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