Optofluidic phantom mimicking optical properties of porcine livers
| Autor: | Mark Wilson, Gerard L. Coté, Michael J. McShane, Travis J. King, Ruiqi Long, Tony J. Akl, M. Nance Ericson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Liver perfusion
Materials science 01 natural sciences Imaging phantom Soft lithography 030218 nuclear medicine & medical imaging 010309 optics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Optics 0103 physical sciences Lobules of liver ocis:(280.1415) Biological sensing and sensors Polydimethylsiloxane Calibration Validation and Phantom Studies business.industry ocis:(110.7050) Turbid media Laser Doppler velocimetry Atomic and Molecular Physics and Optics ocis:(160.4760) Optical properties Transplantation ocis:(170.1470) Blood or tissue constituent monitoring chemistry business Perfusion Biotechnology Biomedical engineering |
| Zdroj: | Biomedical Optics Express |
| ISSN: | 2156-7085 |
| Popis: | One strategy for assessing efficacy of a liver transplant is to monitor perfusion and oxygenation after transplantation. An implantable optical sensor is being developed to overcome inadequacies of current monitoring approaches. To facilitate sensor design while minimizing animal use, a polydimethylsiloxane (PDMS)-based liver phantom was developed to mimic the optical properties of porcine liver in the 630-1000 nm wavelength range and the anatomical geometry of liver parenchyma. Using soft lithography to construct microfluidic channels in pigmented elastomer enabled the 2D approximation of hexagonal liver lobules with 15mm sinusoidal channels, which will allow perfusion with blood-mimicking fluids to facilitate the development of the liver perfusion and oxygenation monitoring system. |
| Databáze: | OpenAIRE |
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