The Effect of Dialysis Modality and Membrane Performance on Native Immunity in Dialysis Patients
| Autor: | Katopodis Periklis, Katopodis P. Konstantinos, Mpournaka Spiridoula, Eleftheriadis Theodoros, Papachristou Evangelos, Chardalias Andreas, Tsakas Sotiris, Pappas M. Efthymios, Goumenos S. Dimitrios |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Neutrophils Polymers Phagocytosis medicine.medical_treatment 030232 urology & nephrology Biocompatible Materials Inflammation Hemodiafiltration 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Immune system Renal Dialysis Immunity Internal medicine medicine Humans Sulfones Renal Insufficiency Chronic Dialysis Aged Aged 80 and over business.industry Membranes Artificial General Medicine Middle Aged medicine.disease Immunity Innate Killer Cells Natural Membrane Parathyroid Hormone Female Hemodialysis medicine.symptom business Kidneys Artificial Kidney disease |
| Zdroj: | PRILOZI. 40:25-32 |
| ISSN: | 1857-8985 1857-9345 |
| DOI: | 10.2478/prilozi-2019-0011 |
| Popis: | Chronic Kidney Disease (CKD) is characterized by immune activation with development of chronic inflammation. However, immune deficiency also exists in CKD patients. The number and the activity of Natural Killer cells (NK-cells) are influenced by the biocompatibility of various dialysis membranes. In this study we investigated the effect of dialysis modality and membrane type on NK-cell number and on phagocytic activity of neutrophils in patients on different dialysis methods. Sixty patients were included in the study and divided in three groups of 20 patients each. Patients on conventional hemodialysis using Low Flux membrane (cHD-LF) were included in Group I, patients on conventional dialysis using High Flux membrane (cHD-HF) were included in Group II and patients treated by on-line hemodiafiltration with High Flux polysulphone membrane (on-line HDF) were included in Group III. Native immunity was investigated using the number of NK-cells and the phagocytic activity of neutrophils. NK-cells count was significantly lower (p In conclusion, an impairment of the native immunity represented by NK cell number and phagocytic activity of neutrophils is observed in patients on dialysis. Dialysis modality and membrane performance do not influence the native immunity of dialyzed patients. However, parathormone blood levels are possibly involved in the development of immune system disturbances in such patients. |
| Databáze: | OpenAIRE |
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