Role of omega-3 fatty acid supplementation in inflammation and malignancy
| Autor: | Ellyn M. Lee, David H. Jho, Shawn M. Cole, N. Joseph Espat |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Cachexia MAP Kinase Signaling System Population Inflammation Biology Pharmacology Malignancy 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Animals Humans education education.field_of_study 030109 nutrition & dietetics NF-kappa B medicine.disease Fish oil Eicosapentaenoic acid Clinical trial Complementary and alternative medicine Oncology Eicosapentaenoic Acid Docosahexaenoic acid Dietary Supplements 030211 gastroenterology & hepatology Animal studies medicine.symptom |
| Zdroj: | Integrative cancer therapies. 3(2) |
| ISSN: | 1534-7354 |
| Popis: | Omega-3 fatty acids (FAs), which include eicosapentaenoic acid (EPA) and docosahexaenoic acid, are found in fish oils and have long been investigated as components of therapy for various disease states. Population studies initially revealed the cardioprotective and anti-inflammatory effects of omega-3 FAs and EPA, with subsequent clinical studies supporting the therapeutic role of omega-3 FAs in cardiovascular and chronic inflammatory conditions. Prospective randomized placebo-controlled trials have also demonstrated the utility of omega-3 FA supplementation in malignancy and cancer cachexia. In recent years, in vitro and animal studies have elucidated some of the mechanistic explanations underlying the wide range of biological effects produced by omega-3 FAs and EPA, including their antiproliferative and anticachectic actions in malignancy. In this review, the authors discuss the recent progress made with omega-3 FAs, focusing on the advances in mechanistic understanding and the results of clinical trials. |
| Databáze: | OpenAIRE |
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