IFN-γ in Combination with IL-3 Accelerates Platelet Recovery in Mice with 5-Fluorouracil-Induced Marrow Aplasia
| Autor: | Akira Harashima, Motoshi Namba, Noboru Izumi, Yoshihiro Nishida, Tsunetaka Ohta, Masashi Kurimoto, Hiroyoshi Tahata, Yasunori Okuda, Kazue Tsuji-Takayama |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Immunology Interferon-gamma Mice Megakaryocyte Virology Internal medicine medicine Animals Megakaryocyte Proliferation Platelet Interleukin 3 Platelet Count business.industry Platelet recovery Anemia Aplastic Infusion Pumps Implantable Cell Biology Aplasia medicine.disease Thrombocytopenia Recombinant Proteins Cytokine medicine.anatomical_structure Endocrinology Fluorouracil Drug Therapy Combination Interleukin-3 business Megakaryocytes medicine.drug |
| Zdroj: | Journal of Interferon & Cytokine Research. 16:447-451 |
| ISSN: | 1557-7465 1079-9907 |
| DOI: | 10.1089/jir.1996.16.447 |
| Popis: | The effects of interferon-gamma (IFN-gamma) on platelet recovery were examined in mice with marrow aplasia induced by i.p. injection of 250 mg/kg of 5-fluorouracil (5-FU). The cytokine was administrated by microosmotic pump, with an ability to deliver a consistent intact dose of cytokine for 7 consecutive days. Administration of 250 IU/kg/day of IFN-gamma in combination with 10(3) U/kg/day of IL-3, which alone had no effect on platelet counts, diminished the nadir for platelet count and shortened the duration of thrombocytopenia. The effect was comparable to that of higher doses of IL-3 (10(5) U/kg/day). The administration of 250 IU/kg/day of IFN-gamma in combination with 10(3) U/kg/day of IL-3 also induced megakaryocyte proliferation in bone marrow cell cultures. Single administration of either 250 IU/kg/day of IFN-gamma or 10(3) U/kg/day of IL-3 had no significant effects. The effect of this combination was also comparable to that of a higher dose of IL-3 (10(5) U/kg/day). We suggest that IFN-gamma accelerates megakaryocyte development, which leads to platelet production in chemotherapy-induced marrow aplasia. The administration of IFN-gamma in combination with IL-3 might be useful for the management of marrow aplasia. |
| Databáze: | OpenAIRE |
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