Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay

Autor:	U. Vogt, Bogdan Falkiewicz, C. M. Schlotter, Krzysztof P. Bielawski, U. Bosse
Rok vydání:	2000
Předmět:	Oncogene Cancer Biology medicine.disease Gene dosage Molecular biology General Biochemistry Genetics and Molecular Biology ErbB Gene expression Cancer research medicine Viability assay Chemosensitivity assay Ex vivo
Zdroj:	Scopus-Elsevier
ISSN:	1734-154X 0001-527X
Popis:	A pilot study on relationships of selected molecular factors [erbB-1, erbB-2, erbB-3, and c-myc oncogene average gene copy numbers (AGCN); steroid receptors and pS2 gene expression; tumor cells' DNA values] to the ex vivo chemosensitivity of ovarian cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Despite the relatively small number of patients, numerous correlations among the factors tested were found. Nevertheless, only c-myc gene dosage positively affected ex vivo chemosensitivity of tumors tested.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d03bdadc7eca79807ae65801644bd8 https://doi.org/10.18388/abp.2000_4073 Zobrazit plný text záznamu