Testosterone Trajectories and Reference Ranges in a Large Longitudinal Sample of Male Adolescents
| Autor: | Margaret T May, Tomáš Paus, Laura Cousino Klein, Elizabeth J. Susman, Ammar Khairullah, Courtney A. Whetzel, Suzanne M Ingle |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Longitudinal sample medicine.medical_specialty Longitudinal study Adolescent Physiology Epidemiology lcsh:Medicine Reference range Pediatrics Young Adult Testosterone blood Endocrinology Child Development Pediatric Endocrinology Adolescent Medicine Reference Values Sex Hormone-Binding Globulin Internal medicine Medicine and Health Sciences medicine Humans Reproductive Endocrinology Testosterone Longitudinal Studies Young adult Child Pediatric Epidemiology lcsh:Science Multidisciplinary Endocrine Physiology business.industry lcsh:R Age Factors Biology and Life Sciences Testosterone (patch) Growth spurt Circadian Rhythm Reference values lcsh:Q business Research Article Demography |
| Zdroj: | Khairullah, A, Klein, L C, Ingle, S M, May, M T, Whetzel, C A, Susman, E J & Paus, T 2014, ' Testosterone Trajectories and Reference Ranges in a Large Longitudinal Sample of Male Adolescents ', PLoS ONE, vol. 9, no. 9, e108838 . https://doi.org/10.1371/journal.pone.0108838 PLoS ONE, Vol 9, Iss 9, p e108838 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Purpose Pubertal dynamics plays an important role in physical and psychological development of children and adolescents. We aim to provide reference ranges of plasma testosterone in a large longitudinal sample. Furthermore, we describe a measure of testosterone trajectories during adolescence that can be used in future investigations of development. Methods We carried out longitudinal measurements of plasma testosterone in 2,216 samples obtained from 513 males (9 to 17 years of age) from the Avon Longitudinal Study of Parents and Children. We used integration of a model fitted to each participant’s testosterone trajectory to calculate a measure of average exposure to testosterone over adolescence. We pooled these data with corresponding values reported in the literature to provide a reference range of testosterone levels in males between the ages of 6 and 19 years. Results The average values of total testosterone in the ALSPAC sample range from 0.82 nmol/L (Standard Deviation [SD]: 0.09) at 9 years of age to 16.5 (SD: 2.65) nmol/L at 17 years of age; these values are congruent with other reports in the literature. The average exposure to testosterone is associated with different features of testosterone trajectories such as Peak Testosterone Change, Age at Peak Testosterone Change, and Testosterone at 17 years of age as well as the timing of the growth spurt during puberty. Conclusions The average exposure to testosterone is a useful measure for future investigations using testosterone trajectories to examine pubertal dynamics. |
| Databáze: | OpenAIRE |
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