Admission hyperglycemia as an independent predictor of long‐term prognosis in acute myocardial infarction patients without diabetes: A retrospective study

Autor: Qiang Chen, Lin Cai, Xu Chen, Feng Zhu, Si-Yi Li, Xing-Lin Jiang, Lian-Chao Cheng, Cai-Yan Cui, Ming-Gang Zhou, Yu-Mei Zhang, Si-Qi Yang, Tao Ye, Ling-Yao Qi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Blood Glucose
Male
Time Factors
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Myocardial Infarction
030204 cardiovascular system & hematology
0302 clinical medicine
Patient Admission
Cause of Death
Myocardial infarction
Stroke
General Medicine
Articles
Middle Aged
Prognosis
Clinical Science and Care
Cardiovascular Diseases
Acute Disease
Original Article
Female
Admission hyperglycemia
medicine.medical_specialty
China
030209 endocrinology & metabolism
Acute myocardial infarction
Revascularization
Independent predictor
Risk Assessment
Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
Predictive Value of Tests
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Diabetes Mellitus
Humans
In patient
Aged
Retrospective Studies
business.industry
Diabetes status
Retrospective cohort study
RC648-665
medicine.disease
Cerebrovascular Disorders
Long‐term prognosis
Hyperglycemia
business
Zdroj: Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 12, Iss 7, Pp 1244-1251 (2021)
ISSN: 2040-1124
2040-1116
Popis: Aims/Introduction The predictive value of admission hyperglycemia in the long‐term prognosis of acute myocardial infarction patients is still controversial. We aimed to investigate this value based on the diabetes status. Materials and Methods We carried out a multicenter, retrospective study of 1,288 acute myocardial infarction patients enrolled in 11 hospitals between March 2014 and June 2019 in Chengdu, China. The patients were classified into those with diabetes and those without diabetes, each was further divided into: hyperglycemia and non‐hyperglycemia subgroups, according to the optimal cut‐off value of the blood glucose to predict all‐cause mortality during follow up. The end‐points were all‐cause death and major adverse cardiovascular and cerebrovascular events, including all‐cause death, non‐fatal myocardial infarction, vessel revascularization and non‐fatal stroke. Results In the follow‐up period of 15 months, we observed 210 (16.3%), 6 (0.5%), 57 (4.4%) and 34 (2.6%) cases of death, non‐fatal myocardial infarction, revascularization and non‐fatal stroke, respectively. The optimal cut‐off values of admission blood glucose for patients with diabetes and patients without diabetes to predict all‐cause mortality during follow up were 14.80 and 6.77 mmol/L, respectively. We divided patients with diabetes (n = 331) into hyperglycemia (n = 92) and non‐hyperglycemia (n = 239), and patients without diabetes (n = 897) into hyperglycemia (n = 425) and non‐hyperglycemia (n = 472). The cumulative rates of all‐cause death and major adverse cardiovascular and cerebrovascular events among the patients in each hyperglycemia group was higher than that in the corresponding non‐hyperglycemia group (P
The prognostic value of admission hyperglycemia on long‐term prognosis remains elusive, especially in acute myocardial infarction patients with diabetes. Regarding acute myocardial infarction patients, there has been no accurate threshold of admission hyperglycemia to predict mortality. Therefore, in our study, we used different cut‐off values in patients with and without diabetes to discuss their predictive value in the long‐term prognosis of acute myocardial infarction patients.
Databáze: OpenAIRE
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