Effect of prostaglandin E1 and indomethacin on responses of longitudinal muscle of guinea-pig ileum to cholecystokinin
| Autor: | Tamás L. Török, Jozsef Knoll, Szilveszter E. Vizi, Zséli J |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Guinea Pigs Indomethacin Endogeny Ileum Tetrodotoxin In Vitro Techniques digestive system Clonidine Membrane Potentials Norepinephrine chemistry.chemical_compound Phentolamine Internal medicine medicine Animals Prostaglandin E1 Cecum Cholecystokinin Pharmacology Morphine Naloxone Prostaglandins E digestive oral and skin physiology Reserpine Acetylcholine Electric Stimulation medicine.anatomical_structure Endocrinology chemistry Female lipids (amino acids peptides and proteins) hormones hormone substitutes and hormone antagonists Muscle Contraction medicine.drug Hormone Prostaglandin E |
| Zdroj: | European Journal of Pharmacology. 56:139-144 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(79)90443-6 |
| Popis: | The effect of prostaglandin E 1 (PGE 1 ) and indomethacin (IND) cholecystokinin (CCK)-induced contractions of guinea-pig isolated ileum longitudinal muscle were studied. PGE 1 (2.8–28 nM) consistently and dose dependently increased the contractions evoked by CCK (indirect muscle stimulation) or by ACh. IND (2.7μM) decreased the contractions to both compounds and this was reversed with 2.8–7 nM PGE 1 . Pretreatment of the preparations with phentolamine (2.6μM) or pretreatment of the animals with reserpine (2 mg/kg i.p. 24 h before killing) did not affect PGE 1 potentiation or IND inhibition of CCK-induced contractions. The results indicated that PGE 1 potentiated CCK-induced contractions of the longitudinal muscle of guinea-pig ileum by increasing the response to released ACh. Experiments with IND suggested that endogenous PGs may modulate the effect of CCK or related gastrointestinal hormones. |
| Databáze: | OpenAIRE |
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