The Effect of Resveratrol on the Composition and State of Lipids and the Activity of Phospholipase A2 During the Excitation and Regeneration of Somatic Nerves
| Autor: | Elvira Sergeevna Revina, Sergey Ivanovich Pinyaev, Victor V. Revin, Marina Vladimirovna Parchaykina, Georgiy Vladimirovich Maksimov, T. P. Kuzmenko |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Rhythmic excitation Myelinated nerve fiber Physiology Phospholipid Nerve fiber resveratrol lcsh:Physiology 03 medical and health sciences Myelin chemistry.chemical_compound 0302 clinical medicine Phospholipase A2 Physiology (medical) medicine skin and connective tissue diseases phospholipids Diacylglycerol kinase biology lcsh:QP1-981 Chemistry nerve intersection myelinated nerve fibers rhythmic excitation 030104 developmental biology medicine.anatomical_structure nervous system 030220 oncology & carcinogenesis Biophysics biology.protein lipids (amino acids peptides and proteins) Sciatic nerve sense organs |
| Zdroj: | Frontiers in Physiology, Vol 10 (2019) |
| DOI: | 10.3389/fphys.2019.00384/full |
| Popis: | It has been shown that in the somatic nerve's lipids, both during excitation and transection, changes occur with the composition of individual phospholipids and in phospholipids fatty acids, which changes the phase state of the myelin and nerve fiber axolemma lipid bilayer. A main contribution in the nerve degenerative processes is dependent on the composition phospholipid's fatty acid changes during the activation of both Ca2+-dependent and Ca2+-independent phospholipase A2 forms. At the same time, we studded changes in phosphoinisitol (PI) and diacylglycerol (DAG), which depend on the phosphoinositide cycle function during nerve excitation and degeneration processes. It was found that myelin lipids and nerve fiber axolemmas are involved not only in the functioning of the peripheral nerves, but also the pathological processes underlying deep functional and structural disorders. The effect of resveratrol on regeneration processes in the damaged rat sciatic nerve has also been investigated. |
| Databáze: | OpenAIRE |
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