VarGoats project : a dataset of 1159 whole-genome sequences to dissect Capra hircus global diversity

Autor: Denoyelle, L., Talouarn, E., Bardou, P., Colli, L., Alberti, A., Danchin, C., Del Corvo, M., Engelen, S., Orvain, C., Palhiere, I., Rupp, R., Sarry, J., Salavati, M., Amills, M., Clark, E., Crepaldi, P., Faraut, T., Masiga, C. W., Pompanon, F., Rosen, B. D., Stella, A., Van Tassell, C. P., Tosser-Klopp, G., Kijas, J., Guldbrandtsen, B., Kantanen, J., Duby, D., Martin, P., Duclos, D., Allain, D., Arquet, R., Mandonnet, N., Naves, M., Carolan, S., Foran, M., Crisa, A., Marletta, D., Ottino, M., Randi, E., Benjelloun, B., Lenstra, H., Moaeen-ud-Din, M., Reecy, J., Goyache, F., Alvarez, I., Capote, J., Jordana, J., Pons, A., Martinez, A., Molina, A., Rosen, B., Drogemuller, C., Luikart, G., Mruttu, H. A., Gondwe, T., Sikosana, J., Taela, M. D. G., Nash, O.
Přispěvatelé: Agence Nationale de la Recherche (France), Région Occitanie / Pyrénées-Méditerranée, Ministère de l’Enseignement supérieur et de la Recherche (France), Biotechnology and Biological Sciences Research Council (UK), Bill & Melinda Gates Foundation, Department for International Development (UK), Center for Tropical Studies and Conservation (US), University of Edinburgh, Scottish Government's Rural and Environment Science and Analytical Services, Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Système d'Information des GENomes des Animaux d'Elevage (SIGENAE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università cattolica del Sacro Cuore [Piacenza e Cremona] (Unicatt), Génomique métabolique (UMR 8030), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Institut de l'élevage (IDELE), Università cattolica del Sacro Cuore [Milano] (Unicatt), The Roslin Institute, Biotechnology and Biological Sciences Research Council (BBSRC), Centre for Tropical Livestock Genetics and Health [Edimburgh] (CTLGH), Centre for Research in Agricultural Genomics (CRAG), Università degli Studi di Milano = University of Milan (UNIMI), Tropical Institute of Development Innovations (TRIDI), USDA Agricultural Research Service [Beltsville, Maryland], USDA-ARS : Agricultural Research Service, Consiglio Nazionale delle Ricerche [Milano] (CNR), CSIRO Agriculture and Food (CSIRO), Unité de Recherches Zootechniques (URZ), APIS-GENE, Occitanie region, Ministere de l'Enseignement superieur, de la Recherche et de l'Innovation, United States Agency for International Development (USAID), CGIAR:OPP1127286, ACTIVEGOAT & CAPRISNP projects, UK Research & Innovation (UKRI) : BBS/OS/GC/000012F, ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), ANR-11-INBS-0003,CRB-Anim,Réseau de Centres de Ressources Biologiques pour les animaux domestiques(2011), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE), University of Milan, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
[SDV]Life Sciences [q-bio]
Short Communication
Single-nucleotide polymorphism
610 Medicine & health
Biology
QH426-470
Genome
SF1-1100
Domestication
Animals
Domestication
Genetic Variation
Genomics
Goats
Genome
Genome-Wide Association Study
03 medical and health sciences
Capra hircus
Genetics
Animals
Indel
Ecology
Evolution
Behavior and Systematics
030304 developmental biology
Genetic association
2. Zero hunger
0303 health sciences
Genetic diversity
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
Settore AGR/17 - ZOOTECNICA GENERALE E MIGLIORAMENTO GENETICO
630 Agriculture
Goats
0402 animal and dairy science
Genetic Variation
04 agricultural and veterinary sciences
General Medicine
Genomics
15. Life on land
040201 dairy & animal science
Animal culture
Evolutionary biology
570 Life sciences
biology
590 Animals (Zoology)
Animal Science and Zoology
Reference genome
Genome-Wide Association Study
Zdroj: Denoyelle, Laure; Talouarn, Estelle; Bardou, Philippe; Colli, Licia; Alberti, Adriana; Danchin, Coralie; Del Corvo, Marcello; Engelen, Stéfan; Orvain, Céline; Palhière, Isabelle; Rupp, Rachel; Sarry, Julien; Salavati, Mazdak; Amills, Marcel; Clark, Emily; Crepaldi, Paola; Faraut, Thomas; Masiga, Clet Wandui; Pompanon, François; Rosen, Benjamin D; ... (2021). VarGoats project: a dataset of 1159 whole-genome sequences to dissect Capra hircus global diversity. Genetics, selection, evolution, 53(1), p. 86. BioMed Central 10.1186/s12711-021-00659-6
Genetics, Selection, Evolution : GSE
Genetics Selection Evolution, Vol 53, Iss 1, Pp 1-14 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Genetics Selection Evolution
Genetics Selection Evolution, 2021, 53 (1), 14 p. ⟨10.1186/s12711-021-00659-6⟩
Genetics Selection Evolution, BioMed Central, 2021, 53 (1), 14 p. ⟨10.1186/s12711-021-00659-6⟩
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
2021, ' VarGoats project : a dataset of 1159 whole-genome sequences to dissect Capra hircus global diversity ', Genetics Selection Evolution, vol. 53, no. 1, pp. 86 . https://doi.org/10.1186/s12711-021-00659-6
ISSN: 0999-193X
1297-9686
Popis: [Background]: Since their domestication 10,500 years ago, goat populations with distinctive genetic backgrounds have adapted to a broad variety of environments and breeding conditions. The VarGoats project is an international 1000-genome resequencing program designed to understand the consequences of domestication and breeding on the genetic diversity of domestic goats and to elucidate how speciation and hybridization have modeled the genomes of a set of species representative of the genus Capra.
[Findings]: A dataset comprising 652 sequenced goats and 507 public goat sequences, including 35 animals representing eight wild species, has been collected worldwide. We identified 74,274,427 single nucleotide polymorphisms (SNPs) and 13,607,850 insertion-deletions (InDels) by aligning these sequences to the latest version of the goat reference genome (ARS1). A Neighbor-joining tree based on Reynolds genetic distances showed that goats from Africa, Asia and Europe tend to group into independent clusters. Because goat breeds from Oceania and Caribbean (Creole) all derive from imported animals, they are distributed along the tree according to their ancestral geographic origin.
[Conclusions]: We report on an unprecedented international effort to characterize the genome-wide diversity of domestic goats. This large range of sequenced individuals represents a unique opportunity to ascertain how the demographic and selection processes associated with post-domestication history have shaped the diversity of this species. Data generated for the project will also be extremely useful to identify deleterious mutations and polymorphisms with causal effects on complex traits, and thus will contribute to new knowledge that could be used in genomic prediction and genome-wide association studies.
We are grateful to France Génomique “Call for high impact projects” (ANR‐10‐INBS‐09‐08) for selecting our project and providing us the resources to sequence 400 goats. We would like to mention that APIS-GENE funded some WGS sequences through ACTIVEGOAT & CAPRISNP projects. We thank the Occitanie region and the Animal Genetics Division of the French National Institute for Agriculture, Food and Environment (INRAE-GA) for financing the PhD of ET. We thank the Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation for financing LD. We thank André Eggen (Illumina) for providing chips to genotype 192 animals. We thank the Animal Genetics Division of the French National Institute for Agriculture, Food and Environment (INRAE-GA) for funding VarGoats2 grant, which allowed DNA extraction and genotyping of 384 animals and CRB-Anim, Grant Agreement ANR-11-INBS-0003, (https://crb-anim.fr/) for funding French local breeds sampling. We thank the Italian Goat and Sheep Breeders Association (AssoNaPa) for supporting in sampling. Whole-genome sequencing libraries for the African goats were prepared and sequenced by Edinburgh Genomics and funded via Biotechnology and Biological Sciences Research Council research grant (BBS/OS/GC/000012F) ‘Reference genome and population sequencing of African goats’ awarded to The Roslin Institute. USDA-ARS with funding from USAID funded the collection of samples from Uganda, Tanzania, Malawi, Mozambique and Zimbabwe. EC and MS were partially supported by the Bill & Melinda Gates Foundation and with UK aid from the UK Government’s Department for International Development (Grant Agreement OPP1127286) under the auspices of the Centre for Tropical Livestock Genetics and Health (CTLGH), established jointly by the University of Edinburgh, SRUC (Scotland’s Rural College), and the International Livestock Research Institute. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Bill & Melinda Gates Foundation nor the UK Government.
Databáze: OpenAIRE
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