Post-synthetic isotopic labeling of an azamacrocyclic ligand

Autor:	Andrea Cornia, Antonio C. Fabretti, Donella Rovai, Mirko Pacchioni, Andrea Bega
Rok vydání:	2002
Předmět:	Nitroso Compounds Chemistry Ligand nitroso compounds Organic Chemistry Inorganic chemistry Alloy engineering.material Biochemistry Isotopic labeling chemistry.chemical_compound Crystallography macrocycles isotopic exchange Drug Discovery Atom engineering Methylene Derivative (chemistry)
Zdroj:	Tetrahedron Letters. 43:771-774
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)02266-3
Popis:	A simple post-synthetic method for the preparation of 1,4,7-triazacyclononane-d12 (90% atom D) is reported. The macrocycle is first converted into 1,4,7-trinitroso-1,4,7-triazacyclononane, whose solid-state and solution properties are herein described. In CD3OD/D2O solution, the trinitroso derivative undergoes fast base-catalyzed H/D exchange on the whole set of methylene hydrogens and can be subsequently denitrosated by reduction with Ni/Al alloy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ca7585b3844fae89b86e6cb946fd14 https://doi.org/10.1016/s0040-4039(01)02266-3 Zobrazit plný text záznamu Full Text from ScienceDirect