Association of serum levels of AngII, KLK1, andACE/KLK1polymorphisms with acute myocardial infarction induced by coronary artery stenosis
| Autor: | Chuan-bao Li, Yun Zhang, Zhuo Li, Jin-bo Feng, Shu-hong Dai, Rui-jian Li, Da-qing Li, Ji-fu Li |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Myocardial Infarction acute myocardial infarction Coronary stenosis Peptidyl-Dipeptidase A 030204 cardiovascular system & hematology Polymerase Chain Reaction Polymorphism Single Nucleotide polymorphism 03 medical and health sciences 0302 clinical medicine Endocrinology Gene Frequency INDEL Mutation Internal medicine Internal Medicine medicine Humans cardiovascular diseases Myocardial infarction Chi-Square Distribution business.industry Angiotensin II High serum Confounding Coronary Stenosis Coronary artery stenosis Middle Aged medicine.disease Logistic Models 030104 developmental biology Increased risk Case-Control Studies kallikrein1 gene Cardiology Original Article Female angiotensin converting enzyme gene business Tissue Kallikreins |
| Zdroj: | Journal of the Renin-Angiotensin-Aldosterone System: JRAAS |
| ISSN: | 1752-8976 1470-3203 |
| Popis: | Introduction:The study aims to confirm the association of acute myocardial infarction (AMI) with serum angiotensin II (AngII), kallikrein1 (KLK1), and ACE/KLK1 polymorphisms.Materials and methods:Serum AngII/KLK1 levels and ACE and KLK1 genotypes were determined in 208 patients with AMI and 216 normal controls. Binary logistic regression was used for data analysis.Results:The differences in serum AngII levels were statistically significant between the groups. After adjusting for potential confounding factors, high serum levels of AngII and KLK1 significantly increased the risk of AMI. The individuals with ACE DD and KLK1 GG genotypes significantly increased the risk of AMI compared with those harboring the ACE II and KLK1 AA genotypes (OR = 8.77, 95% CI = 1.74–44.16).Conclusions:(1) Increasing the serum levels of AngII increased the risk of AMI. (2) The risk of AMI increased significantly when the serum levels of AngII and KLK1 simultaneously increased. (3) Individuals with the combined genotypes of ACE DD and KLK1 GG showed significantly increased risk of AMI compared with those with the combined genotypes of ACE II and KLK1 AA. |
| Databáze: | OpenAIRE |
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