Acute effects of ethanol on action potential and intracellular Ca(2+) transient in cardiac ventricular cells: a simulation study
| Autor: | Jiří Šimurda, Georges Christé, Michal Pásek, Markéta Bébarová, Milena Šimurdová |
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| Rok vydání: | 2015 |
| Předmět: |
Acute effects
medicine.medical_specialty Heart Ventricles Biomedical Engineering Intracellular Space chemistry.chemical_element Action Potentials 030204 cardiovascular system & hematology Calcium Models Biological Contractility 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Humans Computer Simulation Myocytes Cardiac Ethanol effect Ethanol Endoplasmic reticulum Computer Science Applications Rats Cytosol Sarcoplasmic Reticulum Endocrinology chemistry 030217 neurology & neurosurgery Intracellular |
| Zdroj: | Medicalbiological engineeringcomputing. 54(5) |
| ISSN: | 1741-0444 |
| Popis: | Alcohol consumption may result in electrocardiographic changes and arrhythmias, at least partly due to effects of ethanol on cardiac ionic currents. Contractility and intracellular Ca2+ dynamics seem to be altered as well. In this study, we integrated the available (mostly animal) experimental data into previously published models of the rat and human ventricular myocytes to assess the share of ionic current components in ethanol-induced changes in AP configuration and cytosolic Ca2+ transient in ventricular cardiomyocytes. The rat model reproduced well the experimentally observed changes in AP duration (APD) under ethanol (slight prolongation at 0.8 mM and shortening at ≥8 mM). These changes were almost exclusively caused by the ethanol-induced alterations of I K1. The cytosolic Ca2+ transient decreased gradually with the increasing ethanol concentration as a result of the ethanol-induced inhibition of I Ca. In the human model, ethanol produced a dose-dependent APD lengthening, dominated by ethanol effect on I Kr, the key repolarising current in human ventricles. This effect might contribute to the clinically observed proarrhythmic effects of ethanol in predisposed individuals. |
| Databáze: | OpenAIRE |
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