Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy
| Autor: | Elisa Borghi, Andrea Gori, Antonella dʼArminio Monforte, Giusi M. Bellistrì, Stefania Ferramosca, Maria La Francesca, Giulia Morace, Camilla Tincati, Giulia Marchetti |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes DNA Bacterial medicine.medical_treatment Immunology HIV Infections Chromosomal translocation Lymphocyte Activation Pathogenesis Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active Immunopathology medicine Humans Immunology and Allergy Sida Aged Chemotherapy biology business.industry Middle Aged biology.organism_classification medicine.disease Virology CD4 Lymphocyte Count Infectious Diseases Bacterial Translocation Viral disease business CD8 |
| Zdroj: | AIDS. 22:2035-2038 |
| ISSN: | 0269-9370 |
| Popis: | Patients with inefficient CD4+ T-cell recovery on virogically suppressive highly active antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease progression. We show heightened circulating lipopolysaccharide associated with plasma enterobacterial DNA and highly activated Ki67+CD4+CD8+ in 24 immunologic-nonresponders (CD4+ T-cellor = 200; HIV-RNAor = 50) compared with 11 full responders (CD4+ T-cellor= 400; HIV-RNAor = 50). These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation. |
| Databáze: | OpenAIRE |
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