Locally advanced rectal cancer: The importance of a multidisciplinary approach
| Autor: | Mariangela Torniai, Azzurra Onofri, Francesca Morgese, Elena Maccaroni, Michela Tiberi, Stefano Cascinu, Rossana Berardi, Consuelo Ferrini |
|---|---|
| Přispěvatelé: | Berardi, Rossana, Maccaroni, Elena, Onofri, Azzurra, Morgese, Francesca, Torniai, Mariangela, Tiberi, Michela, Ferrini, Consuelo, Cascinu, Stefano |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Colorectal cancer medicine.medical_treatment Locally advanced Late toxicity Multidisciplinary approach Internal medicine Medicine Humans Neoplasm Invasiveness Topic Highlight Molecular Targeted Therapy Radical surgery Neoplasm Metastasis Neoadjuvant therapy Digestive System Surgical Procedures business.industry Rectal Neoplasms General surgery Gastroenterology Standard of Care General Medicine Chemoradiotherapy Adjuvant medicine.disease Total mesorectal excision Neoadjuvant Therapy Sphincter preservation Treatment Outcome Chemotherapy Adjuvant Disease Progression Neoplasm Recurrence Local business |
| Popis: | Rectal cancer accounts for a relevant part of colorectal cancer cases, with a mortality of 4-10/100000 per year. The development of locoregional recurrences and the occurrence of distant metastases both influences the prognosis of these patients. In the last two decades, new multimodality strategies have improved the prognosis of locally advanced rectal cancer with a significant reduction of local relapse and an increase in terms of overall survival. Radical surgery still remains the principal curative treatment and the introduction of total mesorectal excision has significantly achieved a reduction in terms of local recurrence rates. The employment of neoadjuvant treatment, delivered before surgery, also achieved an improved local control and an increased sphincter preservation rate in low-lying tumors, with an acceptable acute and late toxicity. This review describes the multidisciplinary management of rectal cancer, focusing on the effectiveness of neoadjuvant chemoradiotherapy and of post-operative adjuvant chemotherapy both in the standard combined modality treatment programs and in the ongoing research to improve these regimens. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|