Visceral Adiposity Is an Independent Determinant of Hypercoagulability as Measured by Thrombin Generation in Morbid Obesity
| Autor: | Lara N. Roberts, S. J. B. Aylwin, R. Luxton, Paradzai B. Chitongo, Roopen Arya, R. Lyall, R. K. Patel, L. Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system Adiponectin business.industry Class III obesity Adipose tissue Type 2 diabetes coagulation factors medicine.disease Obesity Insulin resistance Endocrinology lcsh:RC666-701 Internal medicine medicine tissue factor pathway inhibitor Original Article venous thrombosis Metabolic syndrome visceral adipose tissue business hemostatic marker Body mass index |
| Zdroj: | TH Open: Companion Journal to Thrombosis and Haemostasis TH Open, Vol 01, Iss 02, Pp e146-e154 (2017) |
| ISSN: | 2512-9465 2567-3459 |
| Popis: | Introduction Increased visceral adipose tissue (VAT) has been shown to be associated with the development of insulin resistance, type 2 diabetes, stroke, and ischemic heart disease. It remains unknown whether fat distribution impacts on coagulation markers and/or the risk of venous thrombosis. This study evaluates markers of hypercoagulability in class III obesity (body mass index [BMI] >40 kg/m2) compared with nonobese controls. We further investigated whether hypercoagulability was influenced by VAT, metabolic syndrome, and metabolic markers, including adiponectin. Patients and Methods Ninety patients were recruited from the obesity clinic at King's College Hospital from November 2009 to December 2011. The inclusion criteria were class III obesity (BMI ≥40 kg/m2) and age 18 to 65 years. A control group (healthy ambulatory participants, with a BMI Results Thrombin generation revealed a significantly increased peak and endogenous thrombin potential in patients compared with controls. Lag time and time to peak (ttP) were also significantly prolonged in patients. VAT was found to have the strongest association with thrombin generation parameters: lag time (β = 0.378; p |
| Databáze: | OpenAIRE |
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