Gender differences in the association of syndecan-4 with myocardial infarction: The population-based Tromsø Study
Autor: | Ellisiv B. Mathiesen, Trine M. Reine, Toralf Melsom, Maja-Lisa Løchen, Bjørn Odvar Eriksen, Svein Olav Kolset, Tom Wilsgaard, Trond Jenssen, Marit Dahl Solbu |
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Rok vydání: | 2018 |
Předmět: |
Male
0301 basic medicine Myocardial Infarction Disease 030204 cardiovascular system & hematology general population Brain Ischemia Cohort Studies 0302 clinical medicine Risk Factors Epidemiology Myocardial infarction Endothelial dysfunction Aged 80 and over education.field_of_study Norway cardiovascular Hazard ratio Middle Aged Stroke gender differences Creatinine Cardiology epidemiology Female Cardiology and Cardiovascular Medicine Adult medicine.medical_specialty animal structures Population Glycocalyx 03 medical and health sciences Sex Factors Internal medicine medicine Albuminuria Humans education Aged Proportional Hazards Models business.industry Proportional hazards model syndecans Atherosclerosis medicine.disease Confidence interval 030104 developmental biology Gene Expression Regulation Syndecan-4 Syndecan-1 business |
Zdroj: | Atherosclerosis. 278:166-173 |
ISSN: | 0021-9150 |
Popis: | Background and aims Cardiovascular disease is a common cause of morbidity and mortality, with gender differences in pathophysiology. The endothelial glycocalyx maintains vascular integrity, and glycocalyx shedding reflects endothelial dysfunction and early atherosclerosis. Syndecan-1 and -4 are components of the glycocalyx, and increased serum levels indicate glycocalyx damage. We hypothesised that increased serum syndecan-1 and -4 were independently associated with myocardial infarction (MI), ischaemic stroke and all-cause mortality in men and women from a general population. Methods Using a case-cohort design, we included 1495 participants from the Tromso Study 2001-02. Syndecan-1 and -4 were measured in serum. Baseline variables also included age, gender, cardiovascular risk factors and urinary albumin-creatinine ratio (ACR). Hazard ratios were assessed using multivariable Cox regression models. Results Between baseline in 2001-02 and December 2007 fatal or non-fatal MI was experienced by 328 and ischaemic stroke by 191 subjects, and 423 participants died. Syndecan-4 was independently associated with MI (hazard ratio per 10 ng/mL increase 1.32; 95% confidence interval 1.06–1.63), but not ischaemic stroke and mortality, and the associations were unchanged by adjustment for urinary ACR. Interaction between syndecan-4 and sex was borderline significant, and in gender-specific analysis, syndecan-4 was associated with MI in women only. Syndecan-1 was not associated with any endpoint. Conclusions Syndecan-4 was associated with incident MI, and the association was stronger in women than in men. This suggests a link between endothelial glycocalyx shedding and coronary heart disease in women. Use of syndecan-4 as a risk marker in clinical setting needs further investigation. |
Databáze: | OpenAIRE |
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