Higher Grades and Repeated Recurrence of Hepatic Encephalopathy May Be Related to High Serum Manganese Levels
| Autor: | Mohamed A. Goda, Soha S. Zakaria, Hanan Soliman, Abdelrahman Kobtan, Ferial El-Kalla |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Pathology Cirrhosis Endocrinology Diabetes and Metabolism Clinical Biochemistry Encephalopathy chemistry.chemical_element Manganese Severity of Illness Index Biochemistry Gastroenterology Inorganic Chemistry Pathogenesis 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine medicine Humans Grading (tumors) Hepatic encephalopathy Aged business.industry Spectrophotometry Atomic Biochemistry (medical) General Medicine Middle Aged medicine.disease Pathophysiology Cross-Sectional Studies chemistry Case-Control Studies Hepatic Encephalopathy 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology Complication business |
| Zdroj: | Biological Trace Element Research. 169:153-158 |
| ISSN: | 1559-0720 0163-4984 |
| Popis: | Hepatic encephalopathy is a serious complication of liver failure. Until now, the precise pathophysiologic mechanisms are not fully determined. It has been demonstrated that manganese plays an important role in the pathogenesis of hepatic encephalopathy. Therefore, we studied manganese levels in serum of cirrhotic patients with hepatic encephalopathy in relation to grading and recurrence of hepatic encephalopathy. One hundred persons were enrolled in the study, 80 cirrhotic patients with or without encephalopathy and 20 healthy controls. Hepatic encephalopathy was diagnosed clinically and by laboratory findings. Serum manganese levels were measured in all participants. The grading of hepatic encephalopathy was significantly correlated to the severity of liver dysfunction. The mean serum manganese level was significantly higher in cirrhotic patients than in controls and in cirrhotic patients with encephalopathy than in those without encephalopathy. It was also significantly higher in patients with advanced grading of hepatic encephalopathy. Serum manganese level was positively correlated to number of recurrences of encephalopathy during a 6-month follow-up period. Serum manganese levels were able to predict recurrence of hepatic encephalopathy within 6 months following the episode. Serum manganese levels are positively correlated to the modified Child-Pugh score of cirrhosis as well as grading and number of recurrences of hepatic encephalopathy. Higher manganese levels seem to be related to worsening of the condition, and its measurement may be used as a predictor of repeated recurrences. |
| Databáze: | OpenAIRE |
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