Change of Coronary Flow Velocity During the Cold Pressor Test Is Related to Endothelial Markers in Subjects With Chest Pain and a Normal Coronary Angiogram
| Autor: | Yun-Seok Choi, Hui-Jeong Hwang, Man-Young Lee, Jae-Beom Lee, Ho-Joong Youn, Chul Soo Park, Woo-Baek Chung, Byung-Ju Shim |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Leptin
Male Chest Pain medicine.medical_specialty CD40 Ligand Provocation test Clinical Investigations Diastole Coronary Artery Disease Doppler echocardiography Coronary Angiography Chest pain Coronary Circulation Internal medicine Humans Medicine Insulin-Like Growth Factor I Adiponectin medicine.diagnostic_test business.industry Cold pressor test Vasospasm General Medicine medicine.disease Coronary Vessels Echocardiography Doppler Surgery Echocardiography Cardiology Regression Analysis Female Endothelium Vascular medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers Blood Flow Velocity |
| Zdroj: | Clinical Cardiology. 35:119-124 |
| ISSN: | 0160-9289 |
| DOI: | 10.1002/clc.20980 |
| Popis: | Background: Several studies demonstrated that endothelial or atherosclerotic biomarkers, including plasma free insulin-like growth factor-I(IGF-I), soluble CD40 ligand (sCD40L), adiponectin, and leptin have an influence on coronary endothelial function. Hypothesis: The aim of the present study was to investigate whether change of coronary flow velocity of the distal left anterior descending artery (LAD) during the cold pressor test (CPT) with transthoracic Doppler echocardiography (TTE) was associated with these biomarkers in subjects with chest pain and a normal coronary angiogram. Methods: In 190 subjects (mean age, 54±11 years; male:female, 113:77) with chest pain and a normal coronary angiogram, peak diastolic velocity (PDV) of the distal LAD during the CPT with TTE was assessed. Acetylcholine provocation test was performed in 58 subjects (mean age, 51±10 years) who were clinically suspected of vasospasm. CPT%PDV was defined as the percent change in PDV during the CPT. Associations between CPT%PDV and clinical parameters were analyzed. Results: According to multiple regression analysis, CPT%PDV was associated with plasma free IGF-I in the entire study population (β=0.295, P |
| Databáze: | OpenAIRE |
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