High education may offer protection against tauopathy in patients with mild cognitive impairment
| Autor: | Kaj Blennow, Arto Nordlund, Pernille J. Olesen, M.H. Gustavsson, Henrik Zetterberg, Carl Eckerström, Sindre Rolstad, Anders Wallin |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Enzyme-Linked Immunosorbent Assay tau Proteins Neuropsychological Tests Statistics Nonparametric Cerebrospinal fluid Internal medicine mental disorders medicine Humans Effects of sleep deprivation on cognitive performance Longitudinal Studies Cognitive impairment Psychiatry Cognitive reserve Aged Psychiatric Status Rating Scales Amyloid beta-Peptides General Neuroscience Cognition General Medicine Middle Aged medicine.disease Peptide Fragments Psychiatry and Mental health Clinical Psychology Brain size Biomarker (medicine) Educational Status Female Tauopathy Geriatrics and Gerontology Psychology Cognition Disorders |
| Zdroj: | Journal of Alzheimer's disease : JAD. 21(1) |
| ISSN: | 1875-8908 |
| Popis: | The concepts of brain and cognitive reserve stem from the observation that premorbid factors (e.g., education) result in variation in the response to brain pathology. Potential early influence of reserve on pathology, as assessed using the cerebrospinal fluid biomarkers total tau (t-tau) and amyloid-beta42, and cognition was explored in mild cognitive impairment (MCI) patients who remained stable over a two-year period. A total of 102 patients with stable MCI grouped on the basis of educational level were compared with regard to biomarker concentrations and cognitive performance. Stable MCI patients with higher education had lower concentrations of t-tau as compared to those with lower education. Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy. |
| Databáze: | OpenAIRE |
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