Clinical and Laboratory changes Consequent to Diethylcarbamazine in Patients with Onchocerciasis *
| Autor: | Lynn Eckhert Fazen, Louis E. Fazen, Robert I. Anderson, Horacio Figueroa Marroquin |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adult
Male Adolescent Population Physiology Urine Eye Onchocerciasis Methylprednisolone Diethylcarbamazine Filariasis Placebos Virology parasitic diseases medicine Humans Child education Microfilariae Skin education.field_of_study integumentary system biology business.industry Middle Aged biology.organism_classification medicine.disease Onchocerca volvulus Diphenhydramine Infectious Diseases Immunology Drug Evaluation Sputum Female Parasitology medicine.symptom Intramuscular injection business medicine.drug |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 25:250-256 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.1976.25.250 |
| Popis: | This controlled study assesses the effect of a single oral dose of diethylcarbamazine (DEC) in a Guatemalan population with light infections of Onchocerca volvulus. From 8 to 24 hours after DEC, microfilariae were found with increased frequency in the urine, blood, and sputum, while the number of microfilariae per mm2 of skin decreased. The onset of signs and symptoms of reaction coincided with the appearance of microfilariae in the body fluids. Motile microfilariae were noted in the anterior chamber of the eye after the administration of diethylcarbamazine. Medication with corticosteroids appeared to reduce the symptoms of reaction without changing the laboratory results. |
| Databáze: | OpenAIRE |
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