Influenza virus vaccination in children with nephrotic syndrome: insignificant risk of relapse
| Autor: | Takashi Ando, Shuichi Ito, Mai Sato, Kenji Ishikura, Yuji Kano, Masao Ogura, Koichi Kamei, Ken Saida, Shingo Ishimori, Hiroko Nagata, Takahisa Yoshikawa |
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| Rok vydání: | 2020 |
| Předmět: |
Adverse event
Male medicine.medical_specialty Nephrotic Syndrome Physiology 030232 urology & nephrology 030204 cardiovascular system & hematology Gee 03 medical and health sciences symbols.namesake Idiopathic nephrotic syndrome 0302 clinical medicine Recurrence Physiology (medical) Internal medicine Influenza Human Odds Ratio medicine Humans Poisson regression Relapse Age of Onset Child Adverse effect Retrospective Studies Influenza virus vaccination business.industry Vaccination Infant medicine.disease Confidence interval Immunization Influenza Vaccines Nephrology Child Preschool Relative risk symbols Original Article Female business Nephrotic syndrome |
| Zdroj: | Clinical and Experimental Nephrology |
| ISSN: | 1437-7799 1342-1751 |
| DOI: | 10.1007/s10157-020-01930-8 |
| Popis: | Background Immunization with various vaccines is considered desirable for children with idiopathic nephrotic syndrome (NS) because of their high risk of severe infections. Vaccinations may precipitate relapses of NS, but there is no available data regarding inactivated influenza (flu) virus vaccines. Methods We retrospectively reviewed the medical records of children with NS who had received flu vaccines between 2002 and 2015. The day of flu vaccination was defined as day 0, and the period between the pre-vaccination and the post-vaccination days was defined as − X to + Y. The risk ratios and their 95% confidence intervals for NS relapse rate were estimated by generalized estimating equation (GEE) Poisson regression. Results A total of 104 pediatric patients received 208 flu vaccines. The mean age at onset of NS was at 4.85 ± 3.87 years old. There were 261 NS relapses between days − 180 and + 180. Compared with the relapse rate in the − 180 to 0 interval (1.19 times/person-year), those in 0 to + 30 (1.23), + 31 to + 60 (1.58), + 61 to + 90 (1.41), + 91 to + 120 (1.41), and + 121 to + 180 (1.32) days groups were slightly increased, but without significance. Multivariate analysis using GEE Poisson regression also showed no significant increase in relapse rate in each day group compared with days − 180 to 0. Risk ratios for NS relapse were significantly higher in children who were treated with steroids at the first vaccination. Conclusions Our results suggest that flu vaccines should not be avoided in children with NS based on the potential for NS relapses. Electronic supplementary material The online version of this article (10.1007/s10157-020-01930-8) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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