Implications of maternal systemic oxidative stress in normal pregnancy and in pregnancy complicated by preeclampsia
| Autor: | Andrei Mihai Măluţan, Nicolae Costin, Lavinia Ioana Sabau, Răzvan Ciortea, Dan Mihu, Carmen Mihaela Mihu |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Physiology Normal pregnancy medicine.disease_cause Antioxidants Preeclampsia Protein Carbonylation Young Adult Pre-Eclampsia Pregnancy medicine Humans Retrospective Studies chemistry.chemical_classification Reactive oxygen species Fetus biology business.industry Obstetrics Moderate level Obstetrics and Gynecology Ceruloplasmin medicine.disease Oxidative Stress chemistry Pediatrics Perinatology and Child Health biology.protein Female Lipid Peroxidation business Reactive Oxygen Species Oxidative stress Hydrogen |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 25(7) |
| ISSN: | 1476-4954 |
| Popis: | To evaluate the intensity of oxidative stress in normal pregnancy and in pregnancy complicated by preeclampsia. To investigate a possible correlation between the intensity of oxidative stress, severity of preeclampsia and the fetal status at birth.A retrospective transversal study was performed in three groups of 80 patients each: Group I--preeclampsia; Group II--normal pregnancy; Group III--control (non-pregnant patients). Degradation products of reactive oxygen species (lipid peroxides and protein carbonyls) and some antioxidants (hydrogen donor capacity and ceruloplasmin) were determined in the serum of patients. The data obtained were processed by descriptive and comparative statistical methods.A moderate level of oxidative stress was found in normal pregnancy. We found statistically significant differences between the control group and the normal pregnancy group (p0.000). In preeclampsia, oxidative stress increases. Statistically significant differences were found in the evaluated parameters between the normal pregnancy group and the preeclampsia group (p0.000). There were no correlations between the intensity of oxidative stress, severity of preeclampsia and the fetal status at birth in the group with preeclampsia.Oxidative stress in preeclampsia is the result of the increase in reactive oxygen species and of the decrease in antioxidants. |
| Databáze: | OpenAIRE |
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