In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives
| Autor: | Zhongjian Chen, Yi Lu, Yanping Huang, Quangang Zhu, Wei Wu, Qin Yu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
LBF
lipid-based formulation Computer science Review AUC area under the curve SLS sodium lauryl sulfate 0302 clinical medicine IVIVC SIF simulated intestinal fluid SCT short-chain triglyceride General Pharmacology Toxicology and Pharmaceutics SEDDS self-emulsifying drug delivery system In silico prediction 0303 health sciences FDA US Food and Drug Administration DDS drug delivery system GI gastrointestinal SMEDDS self-microemulsifying drug delivery system In vitro and in vivo correlations CETP cholesterol ester transfer protein Oral delivery 030220 oncology & carcinogenesis LCT long-chain triglyceride Perspectives HLB hydrophilic–lipophilic balance Lipolysis MCT medium-chain triglyceride RM1-950 Computational biology PK pharmacokinetic Absorption Gastrointestinal digestion 03 medical and health sciences In vivo PBPK physiologically based pharmacokinetic SGF simulated gastric fluid TIM TNO gastrointestinal model 030304 developmental biology BCS biopharmaceutics classification system IVIVC in vitro and in vivo correlation SNEDDS self-nanoemulsifying drug delivery system ANN artificial neural network TNO Netherlands Organization for Applied Scientific Research IVIVR in vitro and in vivo relationship Therapeutics. Pharmacology Cmax peak plasma concentration BE bioequivalence Oral retinoid Tmax time to reach the peak plasma concentration Lipid-based formulation Model |
| Zdroj: | Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2469-2487 (2021) Acta Pharmaceutica Sinica. B |
| ISSN: | 2211-3835 |
| DOI: | 10.1016/j.apsb.2021.03.025 |
| Popis: | Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo correlations (IVIVCs) for LBFs is quite challenging, owing to a complex in vivo processing of these formulations. In this paper, we start with a brief introduction on the gastrointestinal digestion of lipid/LBFs and its relation to enhanced oral drug absorption; based on the concept of IVIVCs, the current status of in vitro models to establish IVIVCs for LBFs is reviewed, while future perspectives in this field are discussed. In vitro tests, which facilitate the understanding and prediction of the in vivo performance of solid dosage forms, frequently fail to mimic the in vivo processing of LBFs, leading to inconsistent results. In vitro digestion models, which more closely simulate gastrointestinal physiology, are a more promising option. Despite some successes in IVIVC modeling, the accuracy and consistency of these models are yet to be validated, particularly for human data. A reliable IVIVC model can not only reduce the risk, time, and cost of formulation development but can also contribute to the formulation design and optimization, thus promoting the clinical translation of LBFs. Graphical abstract In vitro and in vivo correlations (IVIVCs) are powerful tools for preparation development. Constructing IVIVCs for lipid-based formulations is rather challenging. This article reviews the current status and future perspectives in this field.Image 1 |
| Databáze: | OpenAIRE |
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