Effect of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and smoking in COPD
| Autor: | Naglaa F. Ghoname, Ayman H. Abd El-Zaher, Ahmed Sh. Mohamed, Hala M Nagy, Gihan Farouk |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
lcsh:RC705-779
education.field_of_study COPD business.industry Disintegrin Population ADAM33 Gene polymorphisms Single-nucleotide polymorphism lcsh:Diseases of the respiratory system medicine.disease respiratory tract diseases Pulmonary function testing Metalloprotease Genotype Immunology Medicine Allele education business CD8 |
| Zdroj: | Egyptian Journal of Chest Disease and Tuberculosis, Vol 61, Iss 4, Pp 275-280 (2012) |
| ISSN: | 0422-7638 |
| DOI: | 10.1016/j.ejcdt.2012.08.005 |
| Popis: | Background: COPD is characterized by air flow limitation that is not fully reversed and associated with an influx of neutrophils, macrophages and CD8 T lymphocytes in the airways. The disease is characterized by airflow limitation and is associated with an abnormal inflammatory response of the lungs in response to noxious particles or gases and associated with systemic manifestation. Methods: Sixty consecutive patients with COPD and 40 normal healthy individuals were included. All cases and controls were subjected to detection of 2 polymorphic loci (S1 AND Q1) of ADAM33 by PCR-RFLP technique. Results: The percentage of S1 and Q1 AA genotype and A allele were significantly increased in control than in COPD patients while there was significant increase in S1 and Q1 GG genotype and G allele in COPD patients than in control (p 0.05, whereas there was significant increase in ADAM33 S1 G allele and Q1 G allele in smoker and non-smoker in COPD patients as compared to their corresponding fellows in control group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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