Angiotensin-converting enzyme and apolipoprotein B polymorphisms in coronary artery disease
| Autor: | Joyce Maria Annicchino-Bizzacchi, Luiz Antonio Machado César, Antonio de Pádua Mansur, Solange Desirée Avakian, José Antonio Franchini Ramires, Desiderio Favarato |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Genotype Apolipoprotein B Coronary Disease Peptidyl-Dipeptidase A Asymptomatic Angina Coronary artery disease Internal medicine medicine Humans Myocardial infarction Aged Apolipoproteins B Univariate analysis Polymorphism Genetic biology business.industry Gene Amplification Angiotensin-converting enzyme Middle Aged medicine.disease biology.protein Cardiology Regression Analysis Female lipids (amino acids peptides and proteins) Chromosome Deletion medicine.symptom Cardiology and Cardiovascular Medicine business Dyslipidemia |
| Zdroj: | The American Journal of Cardiology. 85:1089-1093 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/s0002-9149(00)00701-3 |
| Popis: | The association between angiotensin-converting enzyme (ACE) as well as apolipoprotein B polymorphisms and dyslipidemia and coronary artery disease (CAD) is controversial. We assessed the distribution of ACE insertion and/or deletion, apolipoprotein B signal peptide insertion and/or deletion, and apolipoprotein B Xba I restriction fragment length polymorphisms in 388 nondiabetic patients. We studied 112 patients with angiographically defined asymptomatic CAD or with stable functional classes I and II angina and 139 patients with acute myocardial infarction who were age matched to 137 control subjects. Univariate analysis showed higher prevalence of Xba I X+/X+ genotype in patients with CAD (p = 0.02). ACE and apolipoprotein polymorphisms were not associated with lipid levels and the number of major coronary artery vessels with >50% reduction of lumen diameter. Overall, multivariable regression disclosed traditional risk factors and elevated levels of apolipoprotein B for men and reduced levels of apolipoprotein AI for women as independent variables for CAD. After adjustment for the most important subset of risk factors (age, hypertension, hypercholesterolemia, and smoking), apolipoprotein B Xba I polymorphism was disclosed as an independent variable for CAD. Apolipoprotein B Xba I was also selected as an independent variable for acute myocardial infarction after adjusting for age, hypertension, hypercholesterolemia, and smoking. Thus, in addition to traditional coronary risk factors, apolipoproteins B and AI, and apolipoprotein B Xba I polymorphism could be considered predictors of CAD. |
| Databáze: | OpenAIRE |
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