The relationship between age, axial length and retinal nerve fiber layer thickness in the normal elderly population in Taiwan: The Chiayi eye study in Taiwan

Autor: Pei-Chen Wu, Pei-Lun Wu, Evelyn Jou-Chen Huang, Chien-Neng Kuo, Chien-Hsiung Lai, Yin-Chi King, Shin-Hua Wu, Ching-Lung Chen, Chau-Yin Chen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Aging
Eye Diseases
genetic structures
Nerve fiber layer
lcsh:Medicine
Alzheimer's Disease
Diagnostic Radiology
Geographical Locations
chemistry.chemical_compound
0302 clinical medicine
Nerve Fibers
Elderly
Animal Cells
Medicine and Health Sciences
lcsh:Science
Tomography
Aged
80 and over
Neurons
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Age Factors
Neurodegenerative Diseases
Axial length
medicine.anatomical_structure
Neurology
Optic nerve
Female
Anatomy
Cellular Types
Tomography
Optical Coherence
Research Article
medicine.medical_specialty
Asia
Imaging Techniques
Taiwan
Spectral domain
Research and Analysis Methods
Retina
03 medical and health sciences
Optical coherence tomography
Ocular System
Diagnostic Medicine
Ophthalmology
Elderly population
Mental Health and Psychiatry
medicine
Humans
Aged
business.industry
lcsh:R
Biology and Life Sciences
Retinal
Optic Nerve
Cell Biology
eye diseases
030104 developmental biology
chemistry
Age Groups
Geriatrics
Cellular Neuroscience
People and Places
030221 ophthalmology & optometry
Eyes
Population Groupings
Dementia
lcsh:Q
sense organs
business
Head
Neuroscience
Zdroj: PLoS ONE, Vol 13, Iss 3, p e0194116 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: Aims To interpret how the thickness of the peripapillary retinal nerve fiber layer (RNFL) changes with increasing age, axial length, or anterior chamber depth as measured by spectral domain optical coherence tomography (OCT) in the normal elderly population in Taiwan. Methods A total of 82 volunteers (143 eyes) were enrolled. Generalized estimating equations were used to evaluate the correlation. Results The RNFL was significantly thinner in the superonasal (p = 0.004), inferotemporal (p = 0.046), and temporolower (p = 0.009) segments with age. The same trend was also observed in the superotemporal (p = 0.330) segment, although it was not statistically significant. The global RNFL thickness decreased by 4.97 μm per decade (β = -0.497; p = 0.021), and thinning was significant in the superonasal (-9.90 μm per decade, p < 0.001) and temporolower (-6.78 μm per decade, p < 0.001) segments; the same trend showed borderline significance in the superotemporal (-6.96 μm per decade, p = 0.073) and inferotemporal (-7.23 μm per decade, p = 0.059) segments. In eyes with longer axial length, the RNFLs significantly decreased in the non-temporal segments. Global RNFL thickness decreased by 3.086 μm for each additional millimeter of axial length (β = -3.086; p < 0.001). Conclusions Changes in RNFL thickness were correlated with age in the superonasal, superotemporal, inferotemporal, and temporolower segments, and were correlated with axial length in the non-temporal segments. Anterior chamber depth was not correlated with RNFL thickness.
Databáze: OpenAIRE
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