Effect of acute nitric oxide synthase inhibition in the modulation of heart rate in rats
| Autor: | Cristina Arranz, C Di Verniero, Analia Lorena Tomat, Patricia Arza, A Varela, Ana M. Balaszczuk, Andrea L. Fellet |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
Bradycardia Chronotropic medicine.medical_specialty Physiology Immunology Heart rate Biophysics Blood Pressure Biochemistry Nitric oxide Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Animals Autonomic nervous system Heart Atria Enzyme Inhibitors General Pharmacology Toxicology and Pharmaceutics lcsh:QH301-705.5 Analysis of Variance lcsh:R5-920 biology General Neuroscience Nitric oxide synthase Heart Cell Biology General Medicine Rats Blockade NG-Nitroarginine Methyl Ester Endocrinology Blood pressure lcsh:Biology (General) chemistry Anesthesia biology.protein medicine.symptom lcsh:Medicine (General) Autonomic Nerve Block |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 36, Issue: 5, Pages: 669-676, Published: MAY 2003 Brazilian Journal of Medical and Biological Research v.36 n.5 2003 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 36, Iss 5, Pp 669-676 (2003) |
| Popis: | Acute nitric oxide synthase inhibition with N G-nitro-L-arginine methyl ester (L-NAME) on chronotropic and pressor responses was studied in anesthetized intact rats and rats submitted to partial and complete autonomic blockade. Blood pressure and heart rate were monitored intra-arterially. Intravenous L-NAME injection (7.5 mg/kg) elicited the same hypertensive response in intact rats and in rats with partial (ganglionic and parasympathetic blockade) and complete autonomic blockade (38 +/- 3, 55 +/- 6, 54 +/- 5, 45 +/- 5 mmHg, respectively; N = 9, P = NS). L-NAME-induced bradycardia at the time when blood pressure reached the peak plateau was similar in intact rats and in rats with partial autonomic blockade (43 +/- 8, 38 +/- 5, 46 +/- 6 bpm, respectively; N = 9, P = NS). Rats with combined autonomic blockade showed a tachycardic response to L-NAME (10 3 bpm, P |
| Databáze: | OpenAIRE |
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