Intrinsic functional connectivity, CSF biomarker profiles and their relation to cognitive function in mild cognitive impairment
| Autor: | David Prvulovic, Johannes Pantel, Monika Scheibe, Tarik Karakaya, Jun-Suk Kang, Fabian Fusser, Silke Matura, Andreas Reif, Jan Köhler, Daniel Hartmann, Felix Ehret, Christoph Mayer |
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| Rok vydání: | 2019 |
| Předmět: |
Male
tau Proteins 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Predictive Value of Tests Reference Values Risk Factors medicine Humans Dementia Cognitive Dysfunction 0501 psychology and cognitive sciences Cognitive decline Correlation of Data Biological Psychiatry Default mode network CSF albumin Aged Amyloid beta-Peptides medicine.diagnostic_test Resting state fMRI business.industry 05 social sciences Brain Cognition Middle Aged medicine.disease Magnetic Resonance Imaging Peptide Fragments Psychiatry and Mental health Disease Progression Biomarker (medicine) Female Nerve Net Functional magnetic resonance imaging business Neuroscience Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Acta Neuropsychiatrica. 32:206-213 |
| ISSN: | 1601-5215 0924-2708 |
| Popis: | Mild cognitive impairment (MCI) often precedes Alzheimer’s Dementia (AD), and in a high proportion of individuals affected by MCI, there are already neuropathological processes ongoing that become more evident when patients progress to AD. Accordingly, there is a need for reliable biomarkers to distinguish between normal aging and incipient AD. Recent research suggests that, in addition to established biomarkers such as CSF Aß42, total tau and hyperphosphorylated tau, resting state connectivity established by functional magnetic resonance imaging might also be a feasible biomarker for prodromal stages of AD. In order to explore this possibility, we investigated resting state functional connectivity as well as cerebrospinal fluid (CSF) biomarker profiles in patients with MCI (n = 30; age 66.43 ± 7.06 years) and cognitively healthy controls (n = 38; age 66.89 ± 7.12 years). CSF Aß42, total tau and hyperphosphorylated tau concentrations were correlated with measures of cognitive performance (immediate and delayed recall, global cognition, processing speed). Moreover, MCI-related alterations in intrinsic functional connectivity within the default mode network were investigated using functional resting state MRI. As expected, MCI patients showed decreased CSF Aß42 and increased total tau concentrations. These alterations were associated with cognitive performance. However, there were no differences between MCI patients and cognitively healthy controls regarding intrinsic functional connectivity. In conclusion, our results indicate that CSF protein profiles seem to be more closely related to cognitive decline than alterations in resting state activity. Thus, resting state connectivity might not be a reliable biomarker for early stages of AD. |
| Databáze: | OpenAIRE |
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