MARS: bringing the automation of small-molecule bioanalytical sample preparations to a new frontier
| Autor: | Ellen Rohde, Aldo Costa, Ming Li, Shane Flannelly-King, Lawrence Gan, Judy Chou, Robin Caputo, Lewis Klunk, Hui Xu, Liyu Yang, Rajesh Mikkilineni, Jing Jing |
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| Rok vydání: | 2012 |
| Předmět: |
Quality Control
Computer science Clinical Biochemistry Liquid-Liquid Extraction Nanotechnology Barcode Mass Spectrometry Analytical Chemistry law.invention Automation law Sample preparation Pharmacokinetics General Pharmacology Toxicology and Pharmaceutics Chromatography High Pressure Liquid Graphical user interface business.industry Suite Solid Phase Extraction Proteins General Medicine Process automation system Sample (graphics) Medical Laboratory Technology Management information systems Pharmaceutical Preparations business Software engineering Software |
| Zdroj: | Bioanalysis. 4(11) |
| ISSN: | 1757-6199 |
| Popis: | Background: In recent years, there has been a growing interest in automating small-molecule bioanalytical sample preparations specifically using the Hamilton MicroLab® STAR liquid-handling platform. In the most extensive work reported thus far, multiple small-molecule sample preparation assay types (protein precipitation extraction, SPE and liquid–liquid extraction) have been integrated into a suite that is composed of graphical user interfaces and Hamilton scripts. Using that suite, bioanalytical scientists have been able to automate various sample preparation methods to a great extent. However, there are still areas that could benefit from further automation, specifically, the full integration of analytical standard and QC sample preparation with study sample extraction in one continuous run, real-time 2D barcode scanning on the Hamilton deck and direct Laboratory Information Management System database connectivity. Results: We developed a new small-molecule sample-preparation automation system that improves in all of the aforementioned areas. Conclusion: The improved system presented herein further streamlines the bioanalytical workflow, simplifies batch run design, reduces analyst intervention and eliminates sample-handling error. |
| Databáze: | OpenAIRE |
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