Roux-en-Y gastric bypass increases systemic but not portal bile acid concentrations by decreasing hepatic bile acid uptake in minipigs
| Autor: | G. Baud, Jean-François Goossens, Thomas Hubert, Mehdi Daoudi, Emmanuelle Vallez, Mostafa Kouach, Bart Staels, Valeria Spinelli, Sophie Lestavel, Anne Tailleux, Robert Caiazzo, François Pattou, Oscar Chávez-Talavera, Mohammed Ghunaim |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Swine medicine.drug_class Endocrinology Diabetes and Metabolism education Gastric bypass Gastric Bypass Medicine (miscellaneous) 030209 endocrinology & metabolism Bile Acids and Salts 03 medical and health sciences 0302 clinical medicine Weight loss Internal medicine Weight Loss medicine Animals Nutrition and Dietetics Bile acid business.industry nutritional and metabolic diseases Transporter Venous blood Metabolism Roux-en-Y anastomosis Obesity Morbid Disease Models Animal 030104 developmental biology Endocrinology Liver Swine Miniature medicine.symptom business Acid uptake |
| Zdroj: | International Journal of Obesity. 41:664-668 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/ijo.2017.7 |
| Popis: | Roux-en-Y gastric bypass (RYGB) surgery is widely used in the management of morbid obesity. RYGB improves metabolism independently of weight loss by still unknown mechanisms. Bile acids (BAs) are good candidates to explain this benefit, since they regulate metabolic homeostasis and their systemic concentrations increase upon RYGB. Here we analyzed the mechanisms underlying the increase in systemic BA concentrations after RYGB and the role of the liver therein. To this aim, we used the Göttingen-like minipig, a human-size mammalian model, which allows continuous sampling and simultaneous analysis of pre-hepatic portal and systemic venous blood. BA concentrations and pool composition were measured in portal blood, containing intestinal reabsorbed BAs and compared to systemic blood during a standardized meal test before and after RYGB. Systemic total BA concentrations increased after RYGB, due to an increase in conjugated BAs. Interestingly, the ratio of portal:systemic conjugated BAs decreased after RYGB, indicating a role for the liver in systemic BA concentrations changes. In line, hepatic expression of BA transporter genes decreased after RYGB. Our results show that the increase in systemic BAs after surgery is due to decreased selective hepatic recapture. Thus, alterations in hepatic function contribute to the increase in systemic BAs after RYGB. |
| Databáze: | OpenAIRE |
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