Penetration of levofloxacin into the anterior chamber (aqueous humour) of the human eye after intravenous administration

Autor: J. R. Fontenla, Y. López, E. García-Vázquez, Josep Mensa, M. Sarasa, P. D. Couchard, D. Soy
Rok vydání: 2007
Předmět:
Zdroj: European Journal of Clinical Microbiology & Infectious Diseases. 26:137-140
ISSN: 1435-4373
0934-9723
DOI: 10.1007/s10096-006-0241-9
Popis: In the study presented here, levofloxacin concentrations in serum samples and the aqueous humour (AH) of 16 patients undergoing cataract extraction were measured in order to determine the penetration characteristics of levofloxacin into the AH of the non-inflamed human eye. Cataract removal was performed at various times (from 90 to 270 min) after the end of a 30-min intravenous infusion of 500 mg of levofloxacin. Serum samples were obtained 1 h after the end of levofloxacin administration (Cmax); AH and a second serum sample were taken simultaneously during the operation, and the concentrations of levofloxacin in AH (CAH) and serum (CS) were determined using a rapid high-performance liquid chromatography assay. The mean Cmax was 6.07 μg/ml (range 3.75–9.53 μg/ml, SD 1.83). The mean CAH at the first hour following levofloxacin administration was 1.37 μg/ml (range 1.17–1.6 μg/ml, SD 0.22) and the mean ratio (R=C AH/CS) was 0.26 (range 0.24–0.3, SD 0.02). The mean C AH at 125–270 min following levofloxacin administration was 1.39 μg/ml (range 0.82–1.98 μg/ml, SD 0.33) and the mean R was 0.3 (range 0.15–0.53, SD 0.11). Of 16 patients, 15 had a C AH of >1 μg/ml 1 h after levofloxacin administration. In conclusion, 1 h after administration of 500 mg of levofloxacin, the levels obtained were higher than the MIC at which 90% of methicillin-susceptible Staphylococcus aureus and certain gram-negative bacteria strains are inhibited.
Databáze: OpenAIRE
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