Reproductive toxicity of Roundup WG® herbicide: impairments in ovarian follicles of model organism Danio rerio
| Autor: | Madson Silveira de Melo, Luciane Nezzi, Yara Maria Rauh Müller, Evelise Maria Nazari, Aline Guimarães Pereira, Carla Eliana Davico, Michael L. Jaramillo |
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| Rok vydání: | 2020 |
| Předmět: |
endocrine system
Health Toxicology and Mutagenesis Population Danio Vitelline membrane Perivitelline space 010501 environmental sciences Biology Endocrine Disruptors 01 natural sciences Andrology Ovarian Follicle Follicular phase medicine Environmental Chemistry Animals Ovarian follicle education Zebrafish 0105 earth and related environmental sciences education.field_of_study Herbicides Reproduction General Medicine biology.organism_classification Pollution medicine.anatomical_structure Endocrine disruptor Female Reproductive toxicity |
| Zdroj: | Environmental science and pollution research international. 28(12) |
| ISSN: | 1614-7499 |
| Popis: | Glyphosate-based herbicides are widely used in global agriculture, and their effects on different non-target animal organisms have been the focus of many toxicological studies. Regarding the potential role of glyphosate-based herbicides as an endocrine disruptor, the present study aims to investigate the effects of the herbicide Roundup WG® (RWG) on female reproduction, specifically on the ovarian maturation of Danio rerio. Adult females were exposed to low concentrations of RWG (0.065, 0.65, and 6.5 mg L-1) for 15 days, and then the ovaries were submitted to structural and morphometric procedures, accompanied by analysis of the vitellin protein content. Our results showed an increase of initial ovarian follicle numbers, decrease of late ovarian follicles, and smaller diameter of ovarian follicles in fish exposed to 0.065 and 6.5 mg L-1. The thickness of vitelline envelope was reduced, and the vitellin protein content was increased in the ovarian follicle in the two highest concentrations. Ultrastructural changes in the ovarian follicular component were evident and expressed by the cell index; vacuolization in follicular cells, increase of perivitelline space, and impaired mitochondria in oocytes were observed. Therefore, RWG adversely affects the ovarian maturation in D. rerio, and these changes can lead to reproductive toxicity, compromising population dynamics. |
| Databáze: | OpenAIRE |
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